Unexpected results in the constitution of small supernumerary marker chromosomes

Abstract Traditional approaches for the classification of Small Supernumerary Marker Chromosomes (sSMC), mostly based on FISH techniques, are time-consuming and not always sufficient to fully understand the true complexity of this class of rearrangements. We describe four supernumerary marker chromo...

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Bibliographic Details
Published in:European journal of medical genetics 2012-03, Vol.55 (3), p.185-190
Main Authors: Vetro, Annalisa, Manolakos, Emmanouil, Petersen, Michael B, Thomaidis, Loretta, Liehr, Thomas, Croci, Gianfranco, Franchi, Fabrizia, Marinelli, Maria, Meneghelli, Emanuela, Dal Bello, Babara, Cesari, Stefania, Iasci, Angela, Arrigo, Giulia, Zuffardi, Orsetta
Format: Article
Language:English
Subjects:
Adult
Array-CGH
Child
Chromosomes, Human - genetics
Comparative Genomic Hybridization
Female
Fetus
FISH
Humans
In Situ Hybridization, Fluorescence
Infant, Newborn
Intellectual Disability - genetics
Male
Medical Education
Prenatal diagnosis
Supernumerary marker chromosome
Telomere capture
Trisomy
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Summary:Abstract Traditional approaches for the classification of Small Supernumerary Marker Chromosomes (sSMC), mostly based on FISH techniques, are time-consuming and not always sufficient to fully understand the true complexity of this class of rearrangements. We describe four supernumerary marker chromosomes that, after array-CGH, were interpreted rather differently in respect to the early classification made by conventional cytogenetics and FISH investigations, reporting two types of complex markers which DNA content was overlooked by conventional approaches: 1. the sSMC contains non-contiguous regions of the same chromosome and, 2. the sSMC, initially interpreted as a supernumerary del(15), turns out to be a derivative 15 to which the portion of another chromosome was attached. All are likely derived from partial trisomy rescue events, bringing further demonstration that germline chromosomal imbalances are submitted to intense reshuffling during the embryogenesis, leading to unexpected complexity and changing the present ideas on the composition of supernumerary marker chromosomes.
ISSN:1769-7212
1878-0849
DOI:10.1016/j.ejmg.2012.01.010