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Arteritic anterior ischemic optic neuropathy with positive myeloperoxidase antineutrophil cytoplasmic antibody
Background Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) is related to smallvessel vasculitis. There have been some reports of optic nerve involvements with increased values of MPO-ANCA. We report two cases of anterior ischemic optic neuropathy (AION) in which ANCA-associated vascul...
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| Published in: | Japanese journal of ophthalmology 2010-07, Vol.54 (4), p.344-348 |
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| container_end_page | 348 |
| container_issue | 4 |
| container_start_page | 344 |
| container_title | Japanese journal of ophthalmology |
| container_volume | 54 |
| creator | Shichinohe, Natsuko Shinmei, Yasuhiro Nitta, Takuya Chin, Shinki Yamada, Yosuke Kase, Manabu |
| description | Background
Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) is related to smallvessel vasculitis. There have been some reports of optic nerve involvements with increased values of MPO-ANCA. We report two cases of anterior ischemic optic neuropathy (AION) in which ANCA-associated vasculitis was suspected to be responsible for the pathogenesis.
Cases
A 66-year-old man and a 72-year-old man had ocular symptoms of AION in both eyes with positive MPO-ANCA.
Observations
Both patients showed high erythrocyte sedimentation rate, C-reactive protein, and MPOANCA values at first. Temporal artery biopsies were negative for temporal arteritis, whereas small-vessel vasculitis was found only in the latter patient. Visual dysfunctions remained unchanged after steroid pulse therapy, although laboratory data returned to normal levels after the treatment. Fluorescein angiography revealed selective occlusion of capillaries, arterioles, and precapillaries in the retina and choroid as well as in the optic disc.
Conclusions
The identical characteristics of the angiographic findings of both eyes in the two cases indicated that the obliteration of small vessels in the intraocular arterial system was closely related to MPO-ANCA-associated vasculitis. |
| doi_str_mv | 10.1007/s10384-010-0831-z |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_954575385</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>748936376</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-df41d07d4a8d1986d4c3ef2d0e4125aabde651d594fc3af81347103c6c02d53b3</originalsourceid><addsrcrecordid>eNqFkUtr3TAQRkVoSW4eP6CbYrrJyu2MXvZdhpC0hUA3yVroSnKugm25kp3E-fWRcdpCoXQlMTpzhtFHyAeEzwhQfUkIrOYlIJRQMyxfDsgGJbKSUi7fkQ0AxVKgEEfkOKUHAOCU0UNyRKECqIFvSH8RRxf96E2h--UWYuGT2bsuV8Kw1Hs3xTDocT8XT37cF0NImX90RTe7NgwuhmdvdXKLwGd4zPTet4WZxzC0OnWr2--CnU_J-0a3yZ29nSfk7vrq9vJbefPj6_fLi5vScCrH0jYcLVSW69ritpaWG-YaasFxpELrnXVSoBVb3himmxoZr_JfGGmAWsF27IScr94hhp-TS6Pq8laubXXvwpTUVnBRCVaL_5IVr7dMskpm8tNf5EOYYp_XyJBkFBBphnCFTAwpRdeoIfpOx1khqCU0tYamcmhqCU295J6Pb-Jp1zn7u-NXShmgK5DyU3_v4p_J_7a-AjrbpSo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>746320112</pqid></control><display><type>article</type><title>Arteritic anterior ischemic optic neuropathy with positive myeloperoxidase antineutrophil cytoplasmic antibody</title><source>Springer Nature</source><creator>Shichinohe, Natsuko ; Shinmei, Yasuhiro ; Nitta, Takuya ; Chin, Shinki ; Yamada, Yosuke ; Kase, Manabu</creator><creatorcontrib>Shichinohe, Natsuko ; Shinmei, Yasuhiro ; Nitta, Takuya ; Chin, Shinki ; Yamada, Yosuke ; Kase, Manabu</creatorcontrib><description>Background
Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) is related to smallvessel vasculitis. There have been some reports of optic nerve involvements with increased values of MPO-ANCA. We report two cases of anterior ischemic optic neuropathy (AION) in which ANCA-associated vasculitis was suspected to be responsible for the pathogenesis.
Cases
A 66-year-old man and a 72-year-old man had ocular symptoms of AION in both eyes with positive MPO-ANCA.
Observations
Both patients showed high erythrocyte sedimentation rate, C-reactive protein, and MPOANCA values at first. Temporal artery biopsies were negative for temporal arteritis, whereas small-vessel vasculitis was found only in the latter patient. Visual dysfunctions remained unchanged after steroid pulse therapy, although laboratory data returned to normal levels after the treatment. Fluorescein angiography revealed selective occlusion of capillaries, arterioles, and precapillaries in the retina and choroid as well as in the optic disc.
Conclusions
The identical characteristics of the angiographic findings of both eyes in the two cases indicated that the obliteration of small vessels in the intraocular arterial system was closely related to MPO-ANCA-associated vasculitis.</description><identifier>ISSN: 0021-5155</identifier><identifier>EISSN: 1613-2246</identifier><identifier>DOI: 10.1007/s10384-010-0831-z</identifier><identifier>PMID: 20700804</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Aged ; Angiography ; Antibodies, Antineutrophil Cytoplasmic - blood ; Arterioles ; Arteritis - diagnosis ; Arteritis - drug therapy ; Arteritis - immunology ; Biopsy ; Capillaries ; Choroid - blood supply ; Clinical Investigation ; Fluorescein Angiography ; Glucocorticoids - therapeutic use ; Humans ; Male ; Medicine ; Medicine & Public Health ; Methylprednisolone - therapeutic use ; Ophthalmology ; Optic Disk - blood supply ; Optic Neuropathy, Ischemic - diagnosis ; Optic Neuropathy, Ischemic - drug therapy ; Optic Neuropathy, Ischemic - immunology ; Peroxidase - blood ; Prednisolone - therapeutic use ; Retinal Vessels ; Temporal Arteries - pathology ; Visual Acuity ; Visual Fields</subject><ispartof>Japanese journal of ophthalmology, 2010-07, Vol.54 (4), p.344-348</ispartof><rights>Japanese Ophthalmological Society (JOS) 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-df41d07d4a8d1986d4c3ef2d0e4125aabde651d594fc3af81347103c6c02d53b3</citedby><cites>FETCH-LOGICAL-c426t-df41d07d4a8d1986d4c3ef2d0e4125aabde651d594fc3af81347103c6c02d53b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20700804$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shichinohe, Natsuko</creatorcontrib><creatorcontrib>Shinmei, Yasuhiro</creatorcontrib><creatorcontrib>Nitta, Takuya</creatorcontrib><creatorcontrib>Chin, Shinki</creatorcontrib><creatorcontrib>Yamada, Yosuke</creatorcontrib><creatorcontrib>Kase, Manabu</creatorcontrib><title>Arteritic anterior ischemic optic neuropathy with positive myeloperoxidase antineutrophil cytoplasmic antibody</title><title>Japanese journal of ophthalmology</title><addtitle>Jpn J Ophthalmol</addtitle><addtitle>Jpn J Ophthalmol</addtitle><description>Background
Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) is related to smallvessel vasculitis. There have been some reports of optic nerve involvements with increased values of MPO-ANCA. We report two cases of anterior ischemic optic neuropathy (AION) in which ANCA-associated vasculitis was suspected to be responsible for the pathogenesis.
Cases
A 66-year-old man and a 72-year-old man had ocular symptoms of AION in both eyes with positive MPO-ANCA.
Observations
Both patients showed high erythrocyte sedimentation rate, C-reactive protein, and MPOANCA values at first. Temporal artery biopsies were negative for temporal arteritis, whereas small-vessel vasculitis was found only in the latter patient. Visual dysfunctions remained unchanged after steroid pulse therapy, although laboratory data returned to normal levels after the treatment. Fluorescein angiography revealed selective occlusion of capillaries, arterioles, and precapillaries in the retina and choroid as well as in the optic disc.
Conclusions
The identical characteristics of the angiographic findings of both eyes in the two cases indicated that the obliteration of small vessels in the intraocular arterial system was closely related to MPO-ANCA-associated vasculitis.</description><subject>Aged</subject><subject>Angiography</subject><subject>Antibodies, Antineutrophil Cytoplasmic - blood</subject><subject>Arterioles</subject><subject>Arteritis - diagnosis</subject><subject>Arteritis - drug therapy</subject><subject>Arteritis - immunology</subject><subject>Biopsy</subject><subject>Capillaries</subject><subject>Choroid - blood supply</subject><subject>Clinical Investigation</subject><subject>Fluorescein Angiography</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methylprednisolone - therapeutic use</subject><subject>Ophthalmology</subject><subject>Optic Disk - blood supply</subject><subject>Optic Neuropathy, Ischemic - diagnosis</subject><subject>Optic Neuropathy, Ischemic - drug therapy</subject><subject>Optic Neuropathy, Ischemic - immunology</subject><subject>Peroxidase - blood</subject><subject>Prednisolone - therapeutic use</subject><subject>Retinal Vessels</subject><subject>Temporal Arteries - pathology</subject><subject>Visual Acuity</subject><subject>Visual Fields</subject><issn>0021-5155</issn><issn>1613-2246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqFkUtr3TAQRkVoSW4eP6CbYrrJyu2MXvZdhpC0hUA3yVroSnKugm25kp3E-fWRcdpCoXQlMTpzhtFHyAeEzwhQfUkIrOYlIJRQMyxfDsgGJbKSUi7fkQ0AxVKgEEfkOKUHAOCU0UNyRKECqIFvSH8RRxf96E2h--UWYuGT2bsuV8Kw1Hs3xTDocT8XT37cF0NImX90RTe7NgwuhmdvdXKLwGd4zPTet4WZxzC0OnWr2--CnU_J-0a3yZ29nSfk7vrq9vJbefPj6_fLi5vScCrH0jYcLVSW69ritpaWG-YaasFxpELrnXVSoBVb3himmxoZr_JfGGmAWsF27IScr94hhp-TS6Pq8laubXXvwpTUVnBRCVaL_5IVr7dMskpm8tNf5EOYYp_XyJBkFBBphnCFTAwpRdeoIfpOx1khqCU0tYamcmhqCU295J6Pb-Jp1zn7u-NXShmgK5DyU3_v4p_J_7a-AjrbpSo</recordid><startdate>20100701</startdate><enddate>20100701</enddate><creator>Shichinohe, Natsuko</creator><creator>Shinmei, Yasuhiro</creator><creator>Nitta, Takuya</creator><creator>Chin, Shinki</creator><creator>Yamada, Yosuke</creator><creator>Kase, Manabu</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20100701</creationdate><title>Arteritic anterior ischemic optic neuropathy with positive myeloperoxidase antineutrophil cytoplasmic antibody</title><author>Shichinohe, Natsuko ; Shinmei, Yasuhiro ; Nitta, Takuya ; Chin, Shinki ; Yamada, Yosuke ; Kase, Manabu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-df41d07d4a8d1986d4c3ef2d0e4125aabde651d594fc3af81347103c6c02d53b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Angiography</topic><topic>Antibodies, Antineutrophil Cytoplasmic - blood</topic><topic>Arterioles</topic><topic>Arteritis - diagnosis</topic><topic>Arteritis - drug therapy</topic><topic>Arteritis - immunology</topic><topic>Biopsy</topic><topic>Capillaries</topic><topic>Choroid - blood supply</topic><topic>Clinical Investigation</topic><topic>Fluorescein Angiography</topic><topic>Glucocorticoids - therapeutic use</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methylprednisolone - therapeutic use</topic><topic>Ophthalmology</topic><topic>Optic Disk - blood supply</topic><topic>Optic Neuropathy, Ischemic - diagnosis</topic><topic>Optic Neuropathy, Ischemic - drug therapy</topic><topic>Optic Neuropathy, Ischemic - immunology</topic><topic>Peroxidase - blood</topic><topic>Prednisolone - therapeutic use</topic><topic>Retinal Vessels</topic><topic>Temporal Arteries - pathology</topic><topic>Visual Acuity</topic><topic>Visual Fields</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shichinohe, Natsuko</creatorcontrib><creatorcontrib>Shinmei, Yasuhiro</creatorcontrib><creatorcontrib>Nitta, Takuya</creatorcontrib><creatorcontrib>Chin, Shinki</creatorcontrib><creatorcontrib>Yamada, Yosuke</creatorcontrib><creatorcontrib>Kase, Manabu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Japanese journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shichinohe, Natsuko</au><au>Shinmei, Yasuhiro</au><au>Nitta, Takuya</au><au>Chin, Shinki</au><au>Yamada, Yosuke</au><au>Kase, Manabu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Arteritic anterior ischemic optic neuropathy with positive myeloperoxidase antineutrophil cytoplasmic antibody</atitle><jtitle>Japanese journal of ophthalmology</jtitle><stitle>Jpn J Ophthalmol</stitle><addtitle>Jpn J Ophthalmol</addtitle><date>2010-07-01</date><risdate>2010</risdate><volume>54</volume><issue>4</issue><spage>344</spage><epage>348</epage><pages>344-348</pages><issn>0021-5155</issn><eissn>1613-2246</eissn><abstract>Background
Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) is related to smallvessel vasculitis. There have been some reports of optic nerve involvements with increased values of MPO-ANCA. We report two cases of anterior ischemic optic neuropathy (AION) in which ANCA-associated vasculitis was suspected to be responsible for the pathogenesis.
Cases
A 66-year-old man and a 72-year-old man had ocular symptoms of AION in both eyes with positive MPO-ANCA.
Observations
Both patients showed high erythrocyte sedimentation rate, C-reactive protein, and MPOANCA values at first. Temporal artery biopsies were negative for temporal arteritis, whereas small-vessel vasculitis was found only in the latter patient. Visual dysfunctions remained unchanged after steroid pulse therapy, although laboratory data returned to normal levels after the treatment. Fluorescein angiography revealed selective occlusion of capillaries, arterioles, and precapillaries in the retina and choroid as well as in the optic disc.
Conclusions
The identical characteristics of the angiographic findings of both eyes in the two cases indicated that the obliteration of small vessels in the intraocular arterial system was closely related to MPO-ANCA-associated vasculitis.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>20700804</pmid><doi>10.1007/s10384-010-0831-z</doi><tpages>5</tpages></addata></record> |
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| subjects | Aged Angiography Antibodies, Antineutrophil Cytoplasmic - blood Arterioles Arteritis - diagnosis Arteritis - drug therapy Arteritis - immunology Biopsy Capillaries Choroid - blood supply Clinical Investigation Fluorescein Angiography Glucocorticoids - therapeutic use Humans Male Medicine Medicine & Public Health Methylprednisolone - therapeutic use Ophthalmology Optic Disk - blood supply Optic Neuropathy, Ischemic - diagnosis Optic Neuropathy, Ischemic - drug therapy Optic Neuropathy, Ischemic - immunology Peroxidase - blood Prednisolone - therapeutic use Retinal Vessels Temporal Arteries - pathology Visual Acuity Visual Fields |
| title | Arteritic anterior ischemic optic neuropathy with positive myeloperoxidase antineutrophil cytoplasmic antibody |
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