A statistical view of FMRFamide neuropeptide diversity

FMRFamide-like peptide (FLP) amino acid sequences have been collected and statistically analyzed. FLP amino acid composition as a function of position in the peptide is graphically presented for several major phyla. Results of total amino acid composition and frequencies of pairs of FLP amino acids...

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Bibliographic Details
Published in:Molecular neurobiology 2000-02, Vol.21 (1-2), p.35-56
Main Authors: Espinoza, E, Carrigan, M, Thomas, S G, Shaw, G, Edison, A S
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino acids
Animals
Database Management Systems
FMRFamide - chemistry
Humans
Molecular Sequence Data
Neuropeptides - chemistry
Peptides
Proteins
Sequence Analysis, Protein - methods
Sequence Analysis, Protein - statistics & numerical data
Studies
Citations: Items that cite this one
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Description
Summary:FMRFamide-like peptide (FLP) amino acid sequences have been collected and statistically analyzed. FLP amino acid composition as a function of position in the peptide is graphically presented for several major phyla. Results of total amino acid composition and frequencies of pairs of FLP amino acids have been computed and compared with corresponding values from the entire GenBank protein sequence database. The data for pairwise distributions of amino acids should help in future structure-function studies of FLPs. To aid in future peptide discovery, a computer program and search protocol was developed to identify FLPs from the GenBank protein database without the use of keywords.
ISSN:0893-7648
0893-7648
1559-1182
DOI:10.1385/mn:21:1-2:035