New directions in liposome gene delivery

The history of liposomes, progress in liposome gene delivery, and future directions are discussed. Specific characteristics of liposomes and DNA:liposome complexes have been identified that are essential for optimal delivery and gene expression. Of particular interest are the requirements for increa...

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Bibliographic Details
Published in:Molecular biotechnology 1999-04, Vol.11 (2), p.175-180
Main Authors: TEMPLETON, N. S, LASIC, D. D
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biotechnology
Cations - chemistry
Cations - metabolism
Deoxyribonucleic acid
DNA
DNA - metabolism
Fundamental and applied biological sciences. Psychology
Gene Expression
Gene therapy
Gene Transfer Techniques
Genetic Therapy - methods
Genetic Vectors
Health. Pharmaceutical industry
Humans
Industrial applications and implications. Economical aspects
Lipids
Liposomes - metabolism
Models, Biological
Nucleic Acids - metabolism
Organ Specificity - physiology
Studies
Tissue Distribution
Viruses - genetics
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Summary:The history of liposomes, progress in liposome gene delivery, and future directions are discussed. Specific characteristics of liposomes and DNA:liposome complexes have been identified that are essential for optimal delivery and gene expression. Of particular interest are the requirements for increased delivery and high levels of gene expression in vivo. At present, significant efforts are focused towards achieving specific delivery and gene expression in target organs and tissues.
ISSN:1073-6085
1559-0305
DOI:10.1007/BF02915810