Early activation of the interleukin-23-17 axis in a murine model of oropharyngeal candidiasis

• Published in: Molecular oral microbiology 2010-10, Vol.25 (5), p.343-356
• Main Authors: Saunus, J.M., Wagner, S.A., Matias, M.A., Hu, Y., Zaini, Z.M., Farah, C.S.
• Format: Article
• Language: English
• Subjects: Animal models; Animals; Biological and medical sciences; Candida albicans; Candidiasis; Candidiasis, Oral - genetics; Candidiasis, Oral - immunology; Chemokine CCL2 - immunology; Chemokine CXCL2 - immunology; Chronic Disease; Commensals; Data processing; Dendritic cells; Dendritic Cells - immunology; Dentistry; Disease Models, Animal; Female; Fundamental and applied biological sciences. Psychology; Immunity; Immunity, Innate; Inflammation; Inoculation; Interleukin 12; Interleukin 17; interleukin 17A; Interleukin 23; Interleukin 6; Interleukin-12 - immunology; Interleukin-12 Subunit p40 - deficiency; Interleukin-17 - immunology; Interleukin-23 - immunology; Leukocyte migration; Leukocytes (neutrophilic); Lymph nodes; Macrophages; Macrophages - immunology; Mice; Mice, Inbred C57BL; Mice, Knockout; Microbiology; Miscellaneous; Monocyte chemoattractant protein 1; Mouth Mucosa - immunology; mRNA; Mucosa; Mycology; Neutrophils - immunology; oropharyngeal candidiasis; Phagocytosis; Recombinant Proteins; Specific Pathogen-Free Organisms; Transendothelial and Transepithelial Migration
• ISSN: 2041-1006; 2041-1014
• DOI: 10.1111/j.2041-1014.2010.00570.x

Summary Candida albicans is an oral commensal yeast that causes oropharyngeal candidiasis (OPC) in immunocompromised individuals. The immunological pathways involved in OPC have been revisited after the interleukin‐17 (IL‐17) pathway was implicated in fungal immunity. We studied immediate (