Importance of the Degree of Antigen Polymerization by Detoxification in Modulating the Immunogenicity of Acellular Pertussis Vaccine

For the acellular pertussis vaccine with a high immunogenicity, the concentration, composition and characteristics of acellular pertussis antigens are the crucial points to be considered. Nevertheless, it has not been proved yet whether or not the polymerization degree, one of the characteristics of...

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Bibliographic Details
Published in:Biotechnology and bioprocess engineering 2005-06, Vol.10 (3), p.230-235
Main Authors: Bae, C.S. (GreenCross Vaccine Corp., Youngin, Republic of Korea), E-mail: kdbae@greencrossvaccine.com, Hong, S.S. (GreenCross Vaccine Corp., Youngin, Republic of Korea), Ahn, S.J. (GreenCross Vaccine Corp., Youngin, Republic of Korea), Jang, Y.S. (GreenCross Vaccine Corp., Youngin, Republic of Korea), Hur, B.K. (Inha University, Incheon, Republic of Korea)
Format: Article
Language:English
Subjects:
acellular pertussis vaccine
Antigens
DESINTOXICACION
DETOXIFICATION
Immunogenicity
Lysine
Pertussis
pertussis toxin
Polymerization
polymerization degree
Smallpox
Toxoids
Vaccines
Whooping cough
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Summary:For the acellular pertussis vaccine with a high immunogenicity, the concentration, composition and characteristics of acellular pertussis antigens are the crucial points to be considered. Nevertheless, it has not been proved yet whether or not the polymerization degree, one of the characteristics of formalin-detoxified acellular pertussis antigens, has an influence on vaccine potency. Thus, in the present study, the correlations among detoxification conditions of acellular pertussis bulks, their polymerization degrees and their immunogenicities were examined.
ISSN:1226-8372
1976-3816
DOI:10.1007/BF02932018