Limbic Metabolic Abnormalities in Remote Traumatic Brain Injury and Correlation With Psychiatric Morbidity and Social Functioning

The aim of this study was to investigate limbic metabolic abnormalities in remote traumatic brain injury (TBI) and their psychiatric correlates. Twenty patients and 13 age-matched comparison subjects received complete psychiatric evaluation and brain MRI and MR spectroscopy at 3 Tesla. Patients had...

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Bibliographic Details
Published in:The journal of neuropsychiatry and clinical neurosciences 2010-10, Vol.22 (4), p.370-377
Main Authors: Capizzano, Arístides A, Jorge, Ricardo E, Robinson, Robert G
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adult and adolescent clinical studies
Aged
Aspartic Acid - metabolism
Biological and medical sciences
Brain Diseases, Metabolic - epidemiology
Brain Diseases, Metabolic - etiology
Brain Diseases, Metabolic - pathology
Brain Injuries - complications
Brain Injuries - epidemiology
Brain Injuries - pathology
Brain Mapping
Case-Control Studies
Choline - metabolism
Female
Humans
Injuries of the nervous system and the skull. Diseases due to physical agents
Limbic System - metabolism
Limbic System - pathology
Magnetic Resonance Imaging - methods
Magnetic Resonance Spectroscopy - methods
Male
Medical sciences
Mental Disorders - epidemiology
Middle Aged
Organic mental disorders. Neuropsychology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Social Adjustment
Statistics as Topic
Traumas. Diseases due to physical agents
Young Adult
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Summary:The aim of this study was to investigate limbic metabolic abnormalities in remote traumatic brain injury (TBI) and their psychiatric correlates. Twenty patients and 13 age-matched comparison subjects received complete psychiatric evaluation and brain MRI and MR spectroscopy at 3 Tesla. Patients had reduced NAA to creatine ratio in the left hippocampus relative to comparison subjects (mean=1.3 [SD=0.21] compared with mean=1.55 [SD=0.21]; F=10.73, df=1, 30, p=0.003), which correlated with the Social Functioning Examination scores (r(s)=-0.502, p=0.034). Furthermore, patients with mood disorders had reduced NAA to creatine ratio in the left cingulate relative to patients without mood disorders (1.47 compared with 1.68; F=3.393, df=3, 19, p=0.044). Remote TBI displays limbic metabolic abnormalities, which correlate to social outcome and psychiatric status.
ISSN:0895-0172
1545-7222
DOI:10.1176/jnp.2010.22.4.370