Diagnostic performances of double-phase tc-99m MIBI scintimammography in patients with indeterminate ultrasound findings: visual and quantitative analyses

The aim of the study was to compare the diagnostic performances of visual and quantitative analyses of double-phase Tc-99m methoxyisobutylisonitrile (MIBI) scintimammography (SMM) in patients with ultrasonographically indeterminate findings. SMM (early: 10min; delayed: 3h) was performed on 78 patien...

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Bibliographic Details
Published in:Annals of nuclear medicine 2007-05, Vol.21 (3), p.145-150
Main Authors: Kim, Seong-Jang, Bae, Young-Tae, Lee, Jung S, Kim, In-Ju, Kim, Yong-Ki
Format: Article
Language:English
Subjects:
Breast cancer
Breast Neoplasms - diagnostic imaging
Female
Humans
Image Enhancement - methods
Medical research
Middle Aged
Radionuclide Imaging
Radiopharmaceuticals
Reproducibility of Results
Sensitivity and Specificity
Technetium Tc 99m Sestamibi
Ultrasonography, Mammary
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Summary:The aim of the study was to compare the diagnostic performances of visual and quantitative analyses of double-phase Tc-99m methoxyisobutylisonitrile (MIBI) scintimammography (SMM) in patients with ultrasonographically indeterminate findings. SMM (early: 10min; delayed: 3h) was performed on 78 patients (malignant 66, benign 12). For visual analysis, the five-scoring method was used. For quantitative analysis, ratios of early and delayed lesions to non-lesion (L/Ns) were calculated. When a visual grade of over 3 was used as the cut-off value for the detection of primary breast cancer, the sensitivity and specificity were 86.4%/ and 100%, respectively. The area under the curve (AUC) was 0.972. The optimal L/N ratios were 1.22 for early and 1.1 for delayed images. When early L/N 1.22 was used as the cut-off point, the sensitivity and specificity of SMM were 92.4% and 91.7'%, respectively. The AUC was 0.952. When delayed L/N 1.1 was used as the cut-off value, the sensitivity and specificity were 78.8% and 91.7%, respectively. The AUC was 0.863. Visual interpretation and early L/N were superior to delayed L/N for the detection of breast cancer. This study suggests the possible diagnostic role of visual and quantitative analyses of double-phase SMM for differentiating malignant breast lesions in patients with ultrasonographi-cally indeterminate findings.
ISSN:0914-7187
1864-6433
DOI:10.1007/s12149-006-0002-y