Rapid data acquisition protocol in ECG-gated myocardial perfusion SPECT with Tc-99m-tetrofosmin

Into 25 patients with heart disorders, 99mTc-tetrofosmin 555-740 MBq was injected intravenously at rest. After 40 minutes, ECG-gated myocardial perfusion SPECT was performed with a two detector gamma camera VERTEX (ADAC), setting up two detectors to form a 90-degree angle. Sixteen frames per R-R int...

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Bibliographic Details
Published in:Annals of nuclear medicine 1998-04, Vol.12 (2), p.71-75
Main Authors: Kumita, S, Kumazaki, T, Cho, K, Mizumura, S, Kijima, T, Ishihara, M, Nakajo, H, Sano, J, Tada, Y, Sakai, S, Kusama, Y, Munakata, K
Format: Article
Language:English
Subjects:
Electrocardiography
Heart - diagnostic imaging
Humans
Medical research
Organophosphorus Compounds
Organotechnetium Compounds
Radiopharmaceuticals
Regression Analysis
Time Factors
Tomography, Emission-Computed, Single-Photon - methods
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Summary:Into 25 patients with heart disorders, 99mTc-tetrofosmin 555-740 MBq was injected intravenously at rest. After 40 minutes, ECG-gated myocardial perfusion SPECT was performed with a two detector gamma camera VERTEX (ADAC), setting up two detectors to form a 90-degree angle. Sixteen frames per R-R interval were acquired during a 180 degree rotation from the RAO 45 degrees to the LPO 45 degrees. A pair of data sets with standard (SDA) and rapid data acquisition (RDA) protocols was collected. In an SDA protocol, SPECT imaging was performed for 50 sec per step in 5 degree angular steps (total acquisition time; 15 minutes). An RDA protocol was conducted with 12 sec per step, 6 degree angular steps (acquisition time, 3 minutes). LVEF (%) and LVEDV (ml) quantitated automatically with a QGS program showed excellent correlations between two protocols with correlation coefficients of 0.980 (p < 0.01) and 0.983 (p < 0.01), respectively. Subsequently visual assessment of regional wall motion based on a four-point grading system was carried out with a 3-D cine LV display. High complete agreement was gained with 158 (90.3%) out of total 175 segments, so that assessment of the global and regional LV function with the RDA protocol demonstrated high reliability and feasibility.
ISSN:0914-7187
1864-6433
DOI:10.1007/BF03164832