Scan findings of various myocardial SPECT agents in a case of amyloid polyneuropathy with suspected myocardial involvement

A 31-year-old male having familial amyloid polyneuropathy underwent a Tc-99m(V)-DMSA study to evaluate the myocardial involvement. The patient also underwent T1-201, I-123-BMIPP and I-123-MIBG myocardial SPECT studies to evaluate blood perfusion, fatty acid metabolism and sympathetic function of the...

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Bibliographic Details
Published in:Annals of nuclear medicine 1997-06, Vol.11 (2), p.139-141
Main Authors: Arbab, A S, Koizumi, K, Toyama, K, Arai, T, Yoshitomi, T, Araki, T
Format: Article
Language:English
Subjects:
3-Iodobenzylguanidine
Adult
Amyloid Neuropathies - diagnostic imaging
Amyloidosis - diagnostic imaging
Amyloidosis - metabolism
Amyloidosis - physiopathology
Cardiomyopathies - diagnostic imaging
Cardiomyopathies - metabolism
Cardiomyopathies - physiopathology
Coronary Circulation
Fatty acids
Fatty Acids - metabolism
Humans
Iodine Radioisotopes
Iodobenzenes
Male
Organotechnetium Compounds
Succimer
Technetium Tc 99m Dimercaptosuccinic Acid
Thallium Radioisotopes
Tomography, Emission-Computed, Single-Photon - methods
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Summary:A 31-year-old male having familial amyloid polyneuropathy underwent a Tc-99m(V)-DMSA study to evaluate the myocardial involvement. The patient also underwent T1-201, I-123-BMIPP and I-123-MIBG myocardial SPECT studies to evaluate blood perfusion, fatty acid metabolism and sympathetic function of the heart, respectively. Tc-99m(V)-DMSA SPECT showed uptake to the myocardium indicating myocardial involvement of amyloidosis. Both T1-201 and I-123-BMIPP studies showed normal uptake indicating normal blood perfusion and fatty acid metabolism but I-123-MIBG SPECT showed no uptake to the heart, indicating severe impairment of sympathetic function.
ISSN:0914-7187
1864-6433
DOI:10.1007/BF03164822