Tc-99m-MIBI scintigraphy for detecting parathyroid adenoma and hyperplasia

We performed scintigraphy with technetium-99m-methoxyisobutylisonitrile (MIBI) in 10 patients with parathyroid adenoma (7 lesions) or hyperplasia (9 lesions). Correlation between an amount of accumulation of MIBI and histological types of the lesions were evaluated with special reference to an amoun...

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Bibliographic Details
Published in:Annals of nuclear medicine 1997-03, Vol.11 (1), p.45-49
Main Authors: Arbab, A S, Koizumi, K, Hemmi, A, Toyama, K, Arai, T, Yoshitomi, T, Araki, T
Format: Article
Language:English
Subjects:
Adenoma - diagnostic imaging
Adenoma - ultrastructure
Adult
Aged
Child
Female
Humans
Hyperparathyroidism - diagnostic imaging
Hyperparathyroidism - pathology
Hyperplasia
Male
Microscopy, Electron
Middle Aged
Mitochondria - ultrastructure
Parathyroid Glands - diagnostic imaging
Parathyroid Glands - pathology
Parathyroid Glands - ultrastructure
Parathyroid Neoplasms - diagnostic imaging
Parathyroid Neoplasms - ultrastructure
Radionuclide Imaging
Technetium Tc 99m Sestamibi
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Summary:We performed scintigraphy with technetium-99m-methoxyisobutylisonitrile (MIBI) in 10 patients with parathyroid adenoma (7 lesions) or hyperplasia (9 lesions). Correlation between an amount of accumulation of MIBI and histological types of the lesions were evaluated with special reference to an amount of oxyphilic cell in the lesions. Selected lesions were also evaluated for mitochondrial density by electromicroscopy and showed increased mitochondrial density in the oxyphilic cells. All lesions equal to or above 220 mg showed positive scintigraphic results despite differences in cell types. Undetected lesions were all equal to or below 100 mg. The scintigraphic results for 2 lesions with abundant oxyphilic cells were both positive although those for 11 lesions with abundant chief cells only 6 were positive, probably because these lesions were smaller in the hyperplasia group. In conclusion, MIBI uptake in parathyroid lesions was not dependent on the cell type but either on the size or functional state of the lesions.
ISSN:0914-7187
1864-6433
DOI:10.1007/BF03164759