Microencapsulation methods for delivery of protein drugs

Recent advances in recombinant DNA technology have resulted in development of many new protein drugs. Due to the unique properties of protein drugs, they have to be delivered by parenteral injection. Although delivery of protein drugs by other routes, such as pulmonary and nasal routes, has shown so...

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Bibliographic Details
Published in:Biotechnology and bioprocess engineering 2001-08, Vol.6 (4), p.213-230
Main Authors: Yeo, Yoon, Baek, Namjin, Park, Kinam
Format: Article
Language:English
Subjects:
Biological activity
Coacervation
DNA
Drug delivery
Drug delivery systems
Drug development
Drugs
Drying
Efficiency
Enzymes
Evaporation
Gelation
Lung
Methods
Microencapsulation
Molecular weight
Peptides
Phase separation
Polyelectrolytes
Polyethylene glycol
Polylactic acid
Polymerization
Polymers
Polyvinyl alcohol
Precipitation
Proteins
Recombinant DNA
Reviews
Solvent extraction processes
Solvents
Spray drying
Supercritical fluids
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Summary:Recent advances in recombinant DNA technology have resulted in development of many new protein drugs. Due to the unique properties of protein drugs, they have to be delivered by parenteral injection. Although delivery of protein drugs by other routes, such as pulmonary and nasal routes, has shown some promises, to date most protein drugs are administered by parenteral routs. For long-term delivery of protein drugs by parenteral administration, they have been developed, and the currently used microencapsulation methods are reviewed here. The microencapsulation methods have been divided based on the method used. They are: solvent evaporation/extraction; phase separation (coacervation); spray drying; ionotropic gelation/polyelectrolyte complexation; interfacial polymerization; and supercritical fluid precipitation. Each method is described for its applications, advantages, and limitations.
ISSN:1226-8372
1976-3816
DOI:10.1007/BF02931982