Dynamic covalent chemistry in aid of peptide self-assembly

Self-assembled peptide systems have been widely studied in the context of gaining understanding of the rules that govern biomolecular processes and increasingly as new bio-inspired nanomaterials. Such materials may be designed to be highly dynamic, displaying adaptive and self-healing properties. Th...

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Bibliographic Details
Published in:Current opinion in biotechnology 2010-08, Vol.21 (4), p.401-411
Main Authors: Sadownik, Jan W, Ulijn, Rein V
Format: Article
Language:English
Subjects:
Amides - chemistry
Amino Acid Sequence
Internal Medicine
Ligands
Metals - chemistry
Peptide Library
Peptides - chemistry
Protein Conformation
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Summary:Self-assembled peptide systems have been widely studied in the context of gaining understanding of the rules that govern biomolecular processes and increasingly as new bio-inspired nanomaterials. Such materials may be designed to be highly dynamic, displaying adaptive and self-healing properties. This review focuses on recent approaches, which exploit reversible covalent and noncovalent chemistry in combination with peptide-based self-assembly. Selected examples of recent advances include sulphur and nitrogen-based reversible reactions, metal–ligand coordination and enzyme-assisted transamidation that lead to structures such as catenanes, nanofibres, β-hairpins and coiled-coil assemblies. It is demonstrated that these structures give rise to nanomaterials with emergent properties that are highly sensitive and adaptive to external conditions and may allow for in vitro evolution of novel peptide nanostructures via templating or self-recognition.
ISSN:0958-1669
1879-0429
DOI:10.1016/j.copbio.2010.05.010