Irreversible Leukoencephalopathy in a Chinese Renal Transplant Recipient

Tacrolimus is an immunosuppressive agent that can show a wide variety of neurological side effects, including leukoencephalopathy. The prognosis is usually good with complete neurological recovery after dose reduction or cessation. However, differentiation from progressive multifocal leukoencephalop...

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Bibliographic Details
Published in:Hong Kong journal of nephrology 2010-10, Vol.12 (2), p.77-80
Main Authors: Cheung, Chi Yuen, Fong, Wing Chi, Tang, Kwok Wing, Chau, Ka Foon, Li, Chun Sang
Format: Article
Language:English
Subjects:
leukoencephalopathy
renal transplant
tacrolimus
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Summary:Tacrolimus is an immunosuppressive agent that can show a wide variety of neurological side effects, including leukoencephalopathy. The prognosis is usually good with complete neurological recovery after dose reduction or cessation. However, differentiation from progressive multifocal leukoencephalopathy can sometimes be difficult. We describe the case of a 52-year-old gentleman with severe, irreversible tacrolimus-related leukoencephalopathy 4 months after kidney transplantation.
ISSN:1561-5413
1876-4371
DOI:10.1016/S1561-5413(10)60016-6