Features of the K-complex waves in refractory nocturnal frontal lobe epilepsy

Summary Purpose To investigate the features of the K-complex (Kc) in refractory nocturnal frontal lobe epilepsy (NFLE) and its relationship with spike discharges (Sds) and clinical seizures. Methods Long-term video-electroencephalographic (VEEG) monitoring was used to collect Kc data from NFLE patie...

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Bibliographic Details
Published in:Epilepsy research 2010-12, Vol.92 (2), p.219-225
Main Authors: Si, Yang, Liu, Ling, Li, Qiong, Mu, Jie, Tian, Lin-yu, Chen, Jia-ni, Zhou, Dong
Format: Article
Language:English
Subjects:
Adolescent
Adult
Analysis of Variance
Anticonvulsants. Antiepileptics. Antiparkinson agents
Biological and medical sciences
Data processing
Electroencephalography - methods
Epilepsy, Frontal Lobe - physiopathology
Female
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
K-complex
Male
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Neuropharmacology
NFLE
Pharmacology. Drug treatments
Polysomnography
Sleep - physiology
Sleep Wake Disorders - physiopathology
Statistics as Topic
Time Factors
VEEG
Video Recording - methods
Young Adult
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Summary:Summary Purpose To investigate the features of the K-complex (Kc) in refractory nocturnal frontal lobe epilepsy (NFLE) and its relationship with spike discharges (Sds) and clinical seizures. Methods Long-term video-electroencephalographic (VEEG) monitoring was used to collect Kc data from NFLE patients and age- and sex-matched controls. We compared the morphological and frequency changes in Kcs between the intractable NFLE group and the control group. Also, the morphological changes in Kcs with Sds and seizures were compared with the other Kcs in NFLE patients. Results In the NFLE group, frequency, amplitude, and rising slope (except duration) were higher than in the control group. Out of the 30 seizures recorded, nine (30%) commenced after a Kc. These Kcs had higher amplitudes than the other Kcs in the NFLE group; there was no difference in duration or rising slope. Additionally, 28 (13.86%) of 202 Kcs of the NFLE group occurred in conjunction with Sds; there were no obvious morphological differences compared with other Kcs. Conclusion Kc activity increases in NFLE, especially prior to a clinical seizure. This reflects an unstable sleep condition, which suggests a correlation between Kc and epileptic activities including seizures and Sds.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2010.10.002