Glyphosate–surfactant herbicide-induced reversible encephalopathy

Abstract Glyphosate–surfactant (GlySH) is a commonly used herbicide that has been used in attempted suicide. Most reports of GlySH toxicity in patients have followed ingestion of the commercial product “Round-up” (Monsanto Ltd; Melbourne, Victoria, Australia), which consists of a mixture of glyphosa...

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Bibliographic Details
Published in:Journal of clinical neuroscience 2010-11, Vol.17 (11), p.1472-1473
Main Authors: Malhotra, R.C, Ghia, D.K, Cordato, D.J, Beran, R.G
Format: Article
Language:English
Subjects:
Acidosis - chemically induced
Acidosis - diagnosis
Acute Disease
Aged
Central nervous system
Coma - chemically induced
Coma - diagnosis
EEG
Glasgow Coma Scale
Glycine - analogs & derivatives
Glycine - poisoning
Glyphosate
Herbicide
Herbicides - poisoning
Humans
Male
Neurology
Neurotoxicity
Neurotoxicity Syndromes - diagnosis
Neurotoxicity Syndromes - metabolism
Reversible encephalopathy
Shock, Cardiogenic - chemically induced
Shock, Cardiogenic - diagnosis
Surface-Active Agents - poisoning
Surfactant
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Summary:Abstract Glyphosate–surfactant (GlySH) is a commonly used herbicide that has been used in attempted suicide. Most reports of GlySH toxicity in patients have followed ingestion of the commercial product “Round-up” (Monsanto Ltd; Melbourne, Victoria, Australia), which consists of a mixture of glyphosate (as a isopropylanine salt) and a surfactant (polyoxyethyleneamine). Ingestion of Round-up is reported to cause significant toxicity including nausea, vomiting, oral and abdominal pain. Renal and hepatic impairment and pulmonary oedema may also occur. Impaired consciousness and encephalopathy have been reported as sequelae but there are limited data on the central nervous system (CNS) effects of Round-up toxicity. We report a 71-year-old male who attempted suicide with GlySH and developed a prolonged but reversible encephalopathy suggestive of acute CNS toxicity.
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2010.02.026