Vulnerable disease may induce neointimal coverage after silorimus-eluting stent implantation

• Published in: The American heart journal 2010-09, Vol.160 (3), p.564-569
• Main Authors: Nishino, Masami, MD, PhD, FACC, Hoshida, Shiro, MD, PhD, Taniike, Masayuki, MD, PhD, Kato, Hiroyasu, MD, Egami, Yasuyuki, MD, Shutta, Ryu, MD, Yamaguchi, Hitoshi, MD, PhD, Tanaka, Kenjiro, MD, Tanouchi, Jun, MD, PhD, Yamada, Yoshio, MD, PhD
• Format: Article
• Language: English
• Subjects: Adrenergic receptors; Biological and medical sciences; Cardiology. Vascular system; Cardiovascular; Cholesterol; Coronary vessels; Drug therapy; Heart attacks; Medical sciences; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Stents
• ISSN: 0002-8703; 1097-6744
• DOI: 10.1016/j.ahj.2010.06.043

Background Neointimal formation can protect against thrombosis after sirolimus-eluting stent (SES) implantation; however, promoters of neointimal formation are unknown. Methods Six-month follow-up angioscopy was performed in 141 consecutive patients with SES implantation. All patients received aspirin (100 mg) and ticlopidine (200 mg) daily until angioscopy. We defined 2 grades of neointimal coverage as follows: insufficient coverage including no or partial neointimal coverage of stent struts, and sufficient coverage. The possible promoters of neointimal formation that were evaluated in this study were the condition of coronary artery disease (stable angina or acute coronary syndrome); angioscopic markers, including visible thrombus and plaque color (white or yellow); serum markers, including low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, fasting blood glucose, hemoglobin A1c , high-sensitive C-reactive protein, and fibrinogen; blood pressure and smoking; intervention markers, including stent size and length and intravascular ultrasound measurements; and medication, including statins, anticoagulants, angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers, calcium antagonists, and β-blockers. Results Univariate analysis revealed that high-sensitive C-reactive protein, plaque color, and the condition of coronary artery disease were significantly correlated with the grade of neointimal coverage. Multivariate analysis using these 3 parameters revealed that only acute coronary syndrome (vulnerable disease) significantly promoted neointimal coverage. Conclusion Vulnerable disease may promote neointimal coverage after SES implantation.