Downgrading BIRADS 3 to BIRADS 2 category using a computer-aided microcalcification analysis and risk assessment system for early breast cancer

Abstract This paper explores the potential of a computer-aided diagnosis system to discriminate the real benign microcalcifications among a specific subset of 109 patients with BIRADS 3 mammograms who had undergone biopsy, thus making it possible to downgrade them to BIRADS 2 category. The system de...

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Bibliographic Details
Published in:Computers in biology and medicine 2010-11, Vol.40 (11), p.853-859
Main Authors: Giannakopoulou, Georgia, Spyrou, George M, Antaraki, Argyro, Andreadis, Ioannis, Koulocheri, Dimitra, Zagouri, Flora, Nonni, Afroditi, Filippakis, George M, Nikita, Konstantina S, Ligomenides, Panos A, Zografos, George C
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Benign
Biopsy
BIRADS 3
Breast cancer
Breast Neoplasms - pathology
CAD system
Calcinosis - pathology
Confidence intervals
Diagnosis, Computer-Assisted - methods
Early breast cancer
Female
Humans
Internal Medicine
Mammography
Mammography - methods
Microcalcifications
Middle Aged
Other
Risk Assessment
SVABB
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Summary:Abstract This paper explores the potential of a computer-aided diagnosis system to discriminate the real benign microcalcifications among a specific subset of 109 patients with BIRADS 3 mammograms who had undergone biopsy, thus making it possible to downgrade them to BIRADS 2 category. The system detected and quantified critical features of microcalcifications and classified them on a risk percentage scale for malignancy. The system successfully detected all cancers. Nevertheless, it suggested biopsy for 11/15 atypical lesions. Finally, the system characterized as definitely benign (BIRADS 2) 29/88 benign lesions, previously assigned to BIRADS 3, and thus achieved a reduction of 33% in unnecessary biopsies.
ISSN:0010-4825
1879-0534
DOI:10.1016/j.compbiomed.2010.09.005