Effects of Short-Term Exposure to Haloperidol and Reserpine on Dopamine Turnover in Nigrostriatal System in Rat Brain

Spectrophotometric methods were employed to determine activity of dopamine metabolism enzymes, tyrosine hydroxylase and monoamine oxidase B, in nigrostriatal structures of the brain in Wistar rats after short-term (60 min) haloperidol or reserpine treatment. Activating effect of the test compounds o...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2010-12, Vol.150 (2), p.188-190
Main Authors: Dovedova, E. L, Voronkov, D. N, Khudoerkov, R. M
Format: Article
Language:English
Subjects:
Adaptations
Amine oxidase (flavin-containing)
Animals
Biomedical and Life Sciences
Biomedicine
Brain
Caudate nucleus
Cell Biology
Communications equipment
Corpus Striatum - drug effects
Corpus Striatum - metabolism
Corticosteroids
Dopamine
Dopamine - metabolism
Dopamine Antagonists - administration & dosage
Dopamine Antagonists - pharmacology
Enzymes
Haloperidol
Injections, Intraperitoneal
Internal Medicine
Laboratory Medicine
Male
Metabolism
Monoamine oxidase
Monoamine Oxidase - metabolism
monoamine oxidase B
Nervous system
Neurotransmission
nigrostriatal dopaminergic structures
Pathology
Phenols
Physiological aspects
Rats
Rats, Wistar
Reserpine
Spectrophotometry
Statistics, Nonparametric
Substantia Nigra - drug effects
Substantia Nigra - metabolism
Tyrosine 3-monooxygenase
Tyrosine 3-Monooxygenase - metabolism
tyrosine hydroxylase
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Summary:Spectrophotometric methods were employed to determine activity of dopamine metabolism enzymes, tyrosine hydroxylase and monoamine oxidase B, in nigrostriatal structures of the brain in Wistar rats after short-term (60 min) haloperidol or reserpine treatment. Activating effect of the test compounds on dopamine synthesis, more pronounced in the caudate nucleus, was demonstrated. Utilization of monoamine oxidase B transmitter was activated by haloperidol, but not reserpine. Some peculiarities of response of the nigrostriatal system structures to the test compounds were noted. We hypothesized the presence of a phase of dopamine metabolism activation, aimed at maintenance of dopamine transmission and nervous system adaptation at early terms after reserpine and haloperidol administration.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-010-1101-2