The time of day and the interval since previous meal are associated with plasma zinc concentrations and affect estimated risk of zinc deficiency in young children in Peru and Ecuador

Background/Objectives: Plasma zinc concentration is the preferred biomarker of zinc status, but the time of day and time since previous meals can modify the results. Measuring fasting plasma zinc concentration is not feasible among young children, so adjustments need to be developed for interpreting...

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Bibliographic Details
Published in:European journal of clinical nutrition 2011-02, Vol.65 (2), p.184-190
Main Authors: Arsenault, J E, Wuehler, S E, de Romaña, D L, Penny, M E, Sempértegui, F, Brown, K H
Format: Article
Language:English
Subjects:
692/53
692/699/1702
692/700/1720
Bioindicators
Biological and medical sciences
Biomarkers
Biomarkers - blood
Blood
Child, Preschool
Children
Children & youth
Circadian Rhythm - physiology
Clinical Nutrition
Clinical trials
Dietary Supplements
Ecuador
Epidemiology
Fasting
Fasting - blood
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Health aspects
Humans
Infant
Infection
Internal Medicine
Male
Meals
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Nutrient deficiency
Nutrition
Nutritional Status
original-article
Peru
Physical growth
Plasma
Postprandial Period - physiology
Product/Service Evaluations
Proteins
Public Health
Regression analysis
Regression models
Sampling
Statistical analysis
Statistical methods
Time Factors
Time of use
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vitamin deficiency
Zinc
Zinc - administration & dosage
Zinc - blood
Zinc - deficiency
Zinc in the body
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Summary:Background/Objectives: Plasma zinc concentration is the preferred biomarker of zinc status, but the time of day and time since previous meals can modify the results. Measuring fasting plasma zinc concentration is not feasible among young children, so adjustments need to be developed for interpreting results. Our objective is to develop correction factors to adjust for the effects of time of day and interval since the previous meal when measuring plasma zinc concentrations of young children. Subjects/Methods: We measured plasma zinc concentrations among young Peruvian ( n =297) and Ecuadorian ( n =466) children, and constructed regression models adjusting for time of day, interval since previous meal and infections. Results: Plasma zinc concentrations were positively related to the number of hours since the previous meal in the Peru trial ( r =0.22, P
ISSN:0954-3007
1476-5640
DOI:10.1038/ejcn.2010.234