Preparation and characterization of chitosan–polylactide composites blended with Cloisite 30B for control release of the anticancer drug paclitaxel

Chitosan (CS) and polylactide (PLA) at different ratios were blended with different wt% of montmorillonite (MMT) (Cloisite 30B) solution by the solvent evaporation method. MMT was incorporated in the formulation as a matrix material component which also plays the role of a co-emulsifier in the nanoc...

Full description

Saved in:
Bibliographic Details
Published in:Carbohydrate polymers 2011-01, Vol.83 (2), p.988-994
Main Authors: Nanda, Rajashree, Sasmal, Abhisek, Nayak, P.L.
Format: Article
Language:English
Subjects:
Anticancer drug
antineoplastic agents
Applied sciences
Biodegradable polymers
Biological and medical sciences
chitosan
Composites
Drug delivery
drug delivery systems
evaporation
Exact sciences and technology
Forms of application and semi-finished materials
Fourier transform infrared spectroscopy
General pharmacology
Kinetics
Medical sciences
montmorillonite
nanocomposites
paclitaxel
Pharmaceutical technology. Pharmaceutical industry
pharmacokinetics
Pharmacology. Drug treatments
polylactic acid
Polymer industry, paints, wood
scanning electron microscopy
solvents
Technology of polymers
X-ray diffraction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chitosan (CS) and polylactide (PLA) at different ratios were blended with different wt% of montmorillonite (MMT) (Cloisite 30B) solution by the solvent evaporation method. MMT was incorporated in the formulation as a matrix material component which also plays the role of a co-emulsifier in the nanocomposite preparation. Paclitaxel (PTX) with different concentrations was loaded with CS–PLA/MMT nanocomposites for studying in vitro drug delivery systems. The composites were characterized by FTIR, SEM, and XRD methods. The drug release was studied as a function of, pH and drug concentrations. The kinetics of the drug release was studied in order to ascertain the type of release mechanism. Based on the diffusion as well as the kinetics, the mechanism of the drug release from the composite matrix has been reported.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2010.09.009