Levetiracetam as Adjunctive Antiepileptic Therapy for Patients with Tuberous Sclerosis Complex: A Retrospective Open-Label Trial

Seizures are a common neurologic symptom of tuberous sclerosis complex. The use of levetiracetam as adjunctive antiepileptic therapy was assessed in 20 patients with tuberous sclerosis complex aged 2 to 19 years. In this retrospective evaluation, 40% of patients treated with levetiracetam achieved a...

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Bibliographic Details
Published in:Journal of child neurology 2006-01, Vol.21 (1), p.53-57
Main Authors: Collins, James J., Tudor, Cynthia, Leonard, Jennifer M., Chuck, Gail, Franz, David Neal
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anorexia - chemically induced
Anticonvulsants - administration & dosage
Anticonvulsants - adverse effects
Anticonvulsants - therapeutic use
Behavioral Symptoms - chemically induced
Child
Child, Preschool
Dose-Response Relationship, Drug
Drug Therapy, Combination
Female
Gait Disorders, Neurologic - chemically induced
Humans
Infant
Male
Piracetam - adverse effects
Piracetam - analogs & derivatives
Piracetam - therapeutic use
Retrospective Studies
Seizures - etiology
Seizures - prevention & control
Sleep Initiation and Maintenance Disorders - chemically induced
Treatment Outcome
Tuberous Sclerosis - complications
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Summary:Seizures are a common neurologic symptom of tuberous sclerosis complex. The use of levetiracetam as adjunctive antiepileptic therapy was assessed in 20 patients with tuberous sclerosis complex aged 2 to 19 years. In this retrospective evaluation, 40% of patients treated with levetiracetam achieved a seizure reduction of more than 50%. Levetiracetam was generally well tolerated, and adverse events were relatively uncommon in patients who responded to treatment. The most commonly reported adverse events were behavioral problems. Unstable gait, insomnia, poor appetite, and increased seizure frequency were also reported. Based on these results, the use of levetiracetam as adjunctive antiepileptic therapy can reduce seizure frequency in patients with tuberous sclerosis complex. (J Child Neurol 2006;21:53—57).
ISSN:0883-0738
1708-8283
DOI:10.1177/08830738060210011201