Skeletal site bone mineral density heterogeneity in women and men

The heterogeneity of skeletal bone mineral density, measured on a single dual-energy X-ray absorptiometer, was examined in a large cohort of 7050 women and 702 men referred for investigation of osteoporosis. The men were significantly older (64.8 +/- 13.2 vs 60.2 +/- 11.5 years) and had an increased...

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Bibliographic Details
Published in:Osteoporosis international 2001-05, Vol.12 (5), p.362-365
Main Authors: PHILLIPOV, G, PHILLIPS, P. J
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Adolescent
Adult
Age
Age Factors
Aged
Aged, 80 and over
Biological and medical sciences
Bone Density
Cross-Sectional Studies
Endocrinology
Female
Femur Neck - physiopathology
Fractures
Hormone replacement therapy
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Osteoarticular system. Muscles
Osteoporosis
Osteoporosis - diagnosis
Osteoporosis - physiopathology
Patients
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Reproducibility of Results
Risk Factors
Sensitivity and Specificity
Sex Factors
Software
Spine - physiopathology
Vertebrae
Women
Young adults
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Summary:The heterogeneity of skeletal bone mineral density, measured on a single dual-energy X-ray absorptiometer, was examined in a large cohort of 7050 women and 702 men referred for investigation of osteoporosis. The men were significantly older (64.8 +/- 13.2 vs 60.2 +/- 11.5 years) and had an increased prevalence of nontraumatic fractures (ODR: 2.18; 95% CI: 1.82-2.61). The detection rate (sensitivity) for any osteoporosis (spine or hip) in women was 87.1% and 45.1% when assessed at the anteroposterior (AP) spine and femoral neck respectively. The corresponding osteoporosis detection rate in men was 69.3% and 67.5% at the AP spine and femoral neck respectively. Age-related AP spine degenerative changes increased significantly and at a similar rate for both women and men. Misclassification, that is osteoporosis (T-score < -2.5) at one site and normal (T-score > -1) bone mass at the other, was low in both genders (< 4.5%), but 3.1 (95% CI: 2.1-4.6) times more likely in women when the diagnosis was based on the femoral neck compared with the AP spine. Our findings suggest that there are significant age- and gender-related bone mineral density differences between the spine and hip skeletal sites which have to be considered if only one site is selected for investigation.
ISSN:0937-941X
1433-2965
DOI:10.1007/s001980170103