Assembly of Polycomb complexes and silencing mechanisms

Polycomb complexes assemble at their target sites and silence neighboring genes when these are not actively transcribed. The action of these complexes and of Trithorax complexes bound to the Polycomb Response Element establish alternative silent or derepressed states that are remembered through cell...

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Bibliographic Details
Published in:Genetica 2003-03, Vol.117 (2-3), p.191-197
Main Authors: Pirrotta, Vincenzo, Poux, Sylvain, Melfi, Raffaella, Pilyugin, Maxim
Format: Article
Language:English
Subjects:
Animals
Cell division
Chromatin
DNA-Binding Proteins - genetics
Drosophila - genetics
Drosophila Proteins - genetics
Gene Silencing
Polycomb Repressive Complex 1
Transcription Factors
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Description
Summary:Polycomb complexes assemble at their target sites and silence neighboring genes when these are not actively transcribed. The action of these complexes and of Trithorax complexes bound to the Polycomb Response Element establish alternative silent or derepressed states that are remembered through cell division and maintained for the rest of development. Recent results that may help explain the properties of these states are reviewed.
ISSN:0016-6707
1573-6857
DOI:10.1023/A:1022992011833