Inflammatory myofibroblastic tumor of bone: two cases occurring in long bone

Inflammatory myofibroblastic tumor (IMT) is an unusual tumor composed of differentiated myofibroblastic spindle cells usually accompanied by numerous plasma cells and lymphocytes. IMT was originally described in the lung; occurrence in a long bone is rare. We present two examples of IMT arising in a...

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Bibliographic Details
Published in:Skeletal radiology 2011, Vol.40 (1), p.117-122
Main Authors: Chen, Jianyu, Li, Haigang, Yang, Zehong, Liu, Qingyu, Gao, Ming, Jiang, Xinhua, Cai, Zhaoxi, Liang, Biling, Jiang, Yebin
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Bone Neoplasms - diagnostic imaging
Bone Neoplasms - immunology
Case Report
Diseases of the osteoarticular system
Female
Humans
Humerus - diagnostic imaging
Imaging
Inflammation
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging
Male
Medical sciences
Medicine
Medicine & Public Health
Myofibroblasts - pathology
Nuclear Medicine
Orthopedics
Osteoarticular system. Muscles
Pathology
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Radiology
Tomography, X-Ray Computed
Tumors
Tumors of striated muscle and skeleton
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Summary:Inflammatory myofibroblastic tumor (IMT) is an unusual tumor composed of differentiated myofibroblastic spindle cells usually accompanied by numerous plasma cells and lymphocytes. IMT was originally described in the lung; occurrence in a long bone is rare. We present two examples of IMT arising in a long bone: one in the humerus and one in the femur. In both cases, imaging shows a poorly delineated osteolytic lesion with cortical bone destruction that aggressively extends into surrounding soft tissue. Histologically, the lesion is dominated by differentiated spindle cells with aprominent collagenous stroma and an inflammatory component including plasma cells and lymphocytes, and with positive immunoreactivity for anaplastic lymphoma kinase. The absence of cytologic atypia helps differentiate this lesion from malignant spindle cell tumors.
ISSN:0364-2348
1432-2161
DOI:10.1007/s00256-010-0998-x