Age and microvascular responses to knee extensor exercise in women

This study examined the relation between femoral artery hyperemic responses to leg exercise and microvascular oxygen extraction in nine young [(mean ± S.E.M) Y: 25 ± 1 years] and 13 older (O: 67 ± 1 years) healthy women. Femoral artery blood flow (FBF; Doppler ultrasound), mean arterial pressure (MA...

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Bibliographic Details
Published in:European journal of applied physiology 2008-06, Vol.103 (3), p.343-351
Main Authors: Parker, Beth A., Smithmyer, Sandra L., Ridout, Samuel J., Ray, Chester A., Proctor, David N.
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Adult
Age Factors
Aged
Aging - metabolism
Biomedical and Life Sciences
Biomedicine
Blood Pressure
Blood Volume
Exercise
Female
Femoral Artery - physiopathology
Hemoglobins - metabolism
Human Physiology
Humans
Hyperemia - physiopathology
Knee
Microcirculation - metabolism
Microcirculation - physiopathology
Middle Aged
Muscle Contraction
Occupational Medicine/Industrial Medicine
Original Article
Oxygen - blood
Oxyhemoglobins - metabolism
Quadriceps Muscle - blood supply
Quadriceps Muscle - metabolism
Quadriceps Muscle - physiopathology
Regional Blood Flow
Spectroscopy, Near-Infrared
Sports Medicine
Time Factors
Ultrasonography, Doppler
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Summary:This study examined the relation between femoral artery hyperemic responses to leg exercise and microvascular oxygen extraction in nine young [(mean ± S.E.M) Y: 25 ± 1 years] and 13 older (O: 67 ± 1 years) healthy women. Femoral artery blood flow (FBF; Doppler ultrasound), mean arterial pressure (MAP), and femoral vascular conductance (FVC; FBF/MAP) were assessed at rest and during 9 min of ∼17–18 W single knee extensor exercise. Near-infrared spectroscopy (NIRS) in the vastus lateralis was used to measure changes in deoxyhemoglobin (HHb) and oxyhemoglobin (O 2 Hb) to assess oxygen extraction (Δ HHb), microvascular blood volume (Δ HHb + O 2 Hb), and spatial heterogeneity of blood volume (relative dispersion, defined as the coefficient of variation of measurements from all NIR sensors). During exercise, FBF and FVC were lower ( p   0.10) beyond the fourth min of exercise. In addition, the relative increase in microvascular blood volume was not significantly different during exercise in Y versus O (age effect: p  = 0.87), although Y demonstrated an increase in blood volume heterogeneity in both the active and inactive leg ( p  = 0.02 and
ISSN:1439-6319
1439-6327
DOI:10.1007/s00421-008-0711-0