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Magnetic resonance imaging of high intensity focused ultrasound mediated drug delivery from temperature-sensitive liposomes: An in vivo proof-of-concept study
Temperature-sensitive liposomes (TSLs) co-encapsulating doxorubicin and 250 mM [Gd(HPDO3A)(H 2O)] were evaluated for HIFU-mediated drug delivery under MR image guidance. In vitro studies showed simultaneous and quantitative release of the drug and the MRI contrast agent from the lumen of the TSLs at...
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| Published in: | Journal of controlled release 2011-02, Vol.150 (1), p.102-110 |
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| cites | cdi_FETCH-LOGICAL-c548t-6d6e4476cfbc869ed05ceb16e2a9d4c87a132b4b70bb07e834df4bd0be6aa9363 |
| container_end_page | 110 |
| container_issue | 1 |
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| container_title | Journal of controlled release |
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| creator | de Smet, Mariska Heijman, Edwin Langereis, Sander Hijnen, Nicole M. Grüll, Holger |
| description | Temperature-sensitive liposomes (TSLs) co-encapsulating doxorubicin and 250
mM [Gd(HPDO3A)(H
2O)] were evaluated for HIFU-mediated drug delivery under MR image guidance.
In vitro studies showed simultaneous and quantitative release of the drug and the MRI contrast agent from the lumen of the TSLs at 42
°C, while no leakage was observed over 1 h at 37
°C. In a proof-of-concept study, local hyperthermia has been applied for 30 min in 9L rat tumors using a clinical MR-HIFU system. The local temperature-triggered release of [Gd(HPDO3A)(H
2O)] was monitored with interleaved
T
1 mapping of the tumor tissue. A good correlation between the ΔR
1, the uptake of doxorubicin and the gadolinium concentration in the tumor was found, implying that the
in vivo release of doxorubicin from TSLs can be probed
in situ with the longitudinal relaxation time of the co-released MRI contrast agent.
[Display omitted] |
| doi_str_mv | 10.1016/j.jconrel.2010.10.036 |
| format | article |
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mM [Gd(HPDO3A)(H
2O)] were evaluated for HIFU-mediated drug delivery under MR image guidance.
In vitro studies showed simultaneous and quantitative release of the drug and the MRI contrast agent from the lumen of the TSLs at 42
°C, while no leakage was observed over 1 h at 37
°C. In a proof-of-concept study, local hyperthermia has been applied for 30 min in 9L rat tumors using a clinical MR-HIFU system. The local temperature-triggered release of [Gd(HPDO3A)(H
2O)] was monitored with interleaved
T
1 mapping of the tumor tissue. A good correlation between the ΔR
1, the uptake of doxorubicin and the gadolinium concentration in the tumor was found, implying that the
in vivo release of doxorubicin from TSLs can be probed
in situ with the longitudinal relaxation time of the co-released MRI contrast agent.
[Display omitted]</description><identifier>ISSN: 0168-3659</identifier><identifier>EISSN: 1873-4995</identifier><identifier>DOI: 10.1016/j.jconrel.2010.10.036</identifier><identifier>PMID: 21059375</identifier><identifier>CODEN: JCREEC</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Animals ; Antibiotics, Antineoplastic - administration & dosage ; Antibiotics, Antineoplastic - pharmacokinetics ; Biological and medical sciences ; Contrast agents ; Contrast Media - administration & dosage ; Contrast Media - pharmacokinetics ; doxorubicin ; Doxorubicin - administration & dosage ; Doxorubicin - pharmacokinetics ; Drug delivery ; Focused ultrasound ; Gadolinium ; General pharmacology ; Heterocyclic Compounds - administration & dosage ; Heterocyclic Compounds - pharmacokinetics ; Hyperthermia ; Image guidance ; in vitro studies ; Liposomes - chemistry ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Medical sciences ; Nanomedicine ; neoplasms ; Neoplasms - diagnostic imaging ; Neoplasms - drug therapy ; Oncology ; Organometallic Compounds - administration & dosage ; Organometallic Compounds - pharmacokinetics ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Rats ; Temperature ; Temperature-sensitive liposome ; Ultrasonics ; Ultrasonography</subject><ispartof>Journal of controlled release, 2011-02, Vol.150 (1), p.102-110</ispartof><rights>2010 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c548t-6d6e4476cfbc869ed05ceb16e2a9d4c87a132b4b70bb07e834df4bd0be6aa9363</citedby><cites>FETCH-LOGICAL-c548t-6d6e4476cfbc869ed05ceb16e2a9d4c87a132b4b70bb07e834df4bd0be6aa9363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23922527$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21059375$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Smet, Mariska</creatorcontrib><creatorcontrib>Heijman, Edwin</creatorcontrib><creatorcontrib>Langereis, Sander</creatorcontrib><creatorcontrib>Hijnen, Nicole M.</creatorcontrib><creatorcontrib>Grüll, Holger</creatorcontrib><title>Magnetic resonance imaging of high intensity focused ultrasound mediated drug delivery from temperature-sensitive liposomes: An in vivo proof-of-concept study</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>Temperature-sensitive liposomes (TSLs) co-encapsulating doxorubicin and 250
mM [Gd(HPDO3A)(H
2O)] were evaluated for HIFU-mediated drug delivery under MR image guidance.
In vitro studies showed simultaneous and quantitative release of the drug and the MRI contrast agent from the lumen of the TSLs at 42
°C, while no leakage was observed over 1 h at 37
°C. In a proof-of-concept study, local hyperthermia has been applied for 30 min in 9L rat tumors using a clinical MR-HIFU system. The local temperature-triggered release of [Gd(HPDO3A)(H
2O)] was monitored with interleaved
T
1 mapping of the tumor tissue. A good correlation between the ΔR
1, the uptake of doxorubicin and the gadolinium concentration in the tumor was found, implying that the
in vivo release of doxorubicin from TSLs can be probed
in situ with the longitudinal relaxation time of the co-released MRI contrast agent.
[Display omitted]</description><subject>Animals</subject><subject>Antibiotics, Antineoplastic - administration & dosage</subject><subject>Antibiotics, Antineoplastic - pharmacokinetics</subject><subject>Biological and medical sciences</subject><subject>Contrast agents</subject><subject>Contrast Media - administration & dosage</subject><subject>Contrast Media - pharmacokinetics</subject><subject>doxorubicin</subject><subject>Doxorubicin - administration & dosage</subject><subject>Doxorubicin - pharmacokinetics</subject><subject>Drug delivery</subject><subject>Focused ultrasound</subject><subject>Gadolinium</subject><subject>General pharmacology</subject><subject>Heterocyclic Compounds - administration & dosage</subject><subject>Heterocyclic Compounds - pharmacokinetics</subject><subject>Hyperthermia</subject><subject>Image guidance</subject><subject>in vitro studies</subject><subject>Liposomes - chemistry</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medical sciences</subject><subject>Nanomedicine</subject><subject>neoplasms</subject><subject>Neoplasms - diagnostic imaging</subject><subject>Neoplasms - drug therapy</subject><subject>Oncology</subject><subject>Organometallic Compounds - administration & dosage</subject><subject>Organometallic Compounds - pharmacokinetics</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Temperature</subject><subject>Temperature-sensitive liposome</subject><subject>Ultrasonics</subject><subject>Ultrasonography</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqNkd-O1CAUhxujccfVR1C5MV51hFJo8Waz2fgvWeOF7jWhcNpl0kIFOsm8jM8qnRn1ciUkJIePww--onhJ8JZgwt_ttjvtXYBxW-FjbYspf1RsSNvQshaCPS42mWtLypm4KJ7FuMMYM1o3T4uLimAmaMM2xa-vanCQrEYBonfKaUB2UoN1A_I9urfDPbIugYs2HVDv9RLBoGVMQUW_OIMmMFalXDNhGZCB0e4hZDL4CSWYZggqLQHKeGyRN9FoZx_9BPE9una5OdrbvUdz8L4v88yv0jAnFNNiDs-LJ70aI7w4r5fF3ccPP24-l7ffPn25ub4tNavbVHLDoa4brvtOt1yAwUxDRzhUSphat40itOrqrsFdhxtoaW36ujO4A66UoJxeFm9PfXOMnwvEJCcbNYyjcuCXKAWrOcGC4_8i8zeT5kGyZZQ368gkO5E6-BgD9HIOWUI4SILlalvu5Nm2XG2vZXxM_ep8w9JlD39P_dGbgTdnQEWtxj5kvzb-46ioKlatAV6fuF55qYaQmbvv-SaGMWkJp20mrk4EZAt7C0FGbSGbMjaATtJ4-0DY32jk2KA</recordid><startdate>20110228</startdate><enddate>20110228</enddate><creator>de Smet, Mariska</creator><creator>Heijman, Edwin</creator><creator>Langereis, Sander</creator><creator>Hijnen, Nicole M.</creator><creator>Grüll, Holger</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20110228</creationdate><title>Magnetic resonance imaging of high intensity focused ultrasound mediated drug delivery from temperature-sensitive liposomes: An in vivo proof-of-concept study</title><author>de Smet, Mariska ; Heijman, Edwin ; Langereis, Sander ; Hijnen, Nicole M. ; Grüll, Holger</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c548t-6d6e4476cfbc869ed05ceb16e2a9d4c87a132b4b70bb07e834df4bd0be6aa9363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Antibiotics, Antineoplastic - administration & dosage</topic><topic>Antibiotics, Antineoplastic - pharmacokinetics</topic><topic>Biological and medical sciences</topic><topic>Contrast agents</topic><topic>Contrast Media - administration & dosage</topic><topic>Contrast Media - pharmacokinetics</topic><topic>doxorubicin</topic><topic>Doxorubicin - administration & dosage</topic><topic>Doxorubicin - pharmacokinetics</topic><topic>Drug delivery</topic><topic>Focused ultrasound</topic><topic>Gadolinium</topic><topic>General pharmacology</topic><topic>Heterocyclic Compounds - administration & dosage</topic><topic>Heterocyclic Compounds - pharmacokinetics</topic><topic>Hyperthermia</topic><topic>Image guidance</topic><topic>in vitro studies</topic><topic>Liposomes - chemistry</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medical sciences</topic><topic>Nanomedicine</topic><topic>neoplasms</topic><topic>Neoplasms - diagnostic imaging</topic><topic>Neoplasms - drug therapy</topic><topic>Oncology</topic><topic>Organometallic Compounds - administration & dosage</topic><topic>Organometallic Compounds - pharmacokinetics</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Temperature</topic><topic>Temperature-sensitive liposome</topic><topic>Ultrasonics</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Smet, Mariska</creatorcontrib><creatorcontrib>Heijman, Edwin</creatorcontrib><creatorcontrib>Langereis, Sander</creatorcontrib><creatorcontrib>Hijnen, Nicole M.</creatorcontrib><creatorcontrib>Grüll, Holger</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Smet, Mariska</au><au>Heijman, Edwin</au><au>Langereis, Sander</au><au>Hijnen, Nicole M.</au><au>Grüll, Holger</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic resonance imaging of high intensity focused ultrasound mediated drug delivery from temperature-sensitive liposomes: An in vivo proof-of-concept study</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>2011-02-28</date><risdate>2011</risdate><volume>150</volume><issue>1</issue><spage>102</spage><epage>110</epage><pages>102-110</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><coden>JCREEC</coden><abstract>Temperature-sensitive liposomes (TSLs) co-encapsulating doxorubicin and 250
mM [Gd(HPDO3A)(H
2O)] were evaluated for HIFU-mediated drug delivery under MR image guidance.
In vitro studies showed simultaneous and quantitative release of the drug and the MRI contrast agent from the lumen of the TSLs at 42
°C, while no leakage was observed over 1 h at 37
°C. In a proof-of-concept study, local hyperthermia has been applied for 30 min in 9L rat tumors using a clinical MR-HIFU system. The local temperature-triggered release of [Gd(HPDO3A)(H
2O)] was monitored with interleaved
T
1 mapping of the tumor tissue. A good correlation between the ΔR
1, the uptake of doxorubicin and the gadolinium concentration in the tumor was found, implying that the
in vivo release of doxorubicin from TSLs can be probed
in situ with the longitudinal relaxation time of the co-released MRI contrast agent.
[Display omitted]</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>21059375</pmid><doi>10.1016/j.jconrel.2010.10.036</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0168-3659 |
| ispartof | Journal of controlled release, 2011-02, Vol.150 (1), p.102-110 |
| issn | 0168-3659 1873-4995 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_954610960 |
| source | ScienceDirect Journals |
| subjects | Animals Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - pharmacokinetics Biological and medical sciences Contrast agents Contrast Media - administration & dosage Contrast Media - pharmacokinetics doxorubicin Doxorubicin - administration & dosage Doxorubicin - pharmacokinetics Drug delivery Focused ultrasound Gadolinium General pharmacology Heterocyclic Compounds - administration & dosage Heterocyclic Compounds - pharmacokinetics Hyperthermia Image guidance in vitro studies Liposomes - chemistry Magnetic resonance imaging Magnetic Resonance Imaging - methods Medical sciences Nanomedicine neoplasms Neoplasms - diagnostic imaging Neoplasms - drug therapy Oncology Organometallic Compounds - administration & dosage Organometallic Compounds - pharmacokinetics Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Rats Temperature Temperature-sensitive liposome Ultrasonics Ultrasonography |
| title | Magnetic resonance imaging of high intensity focused ultrasound mediated drug delivery from temperature-sensitive liposomes: An in vivo proof-of-concept study |
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