Genetic profile characterization of 10 X-STRs in four populations of the southeastern region of Brazil

Ten X-chromosomal short tandem repeats (DXS8378, DXS9902, DXS7132, DXS9898, DXS6809, DXS6789, DXS7133, GATA172D05, GATA31E08 and DXS7423) were analyzed in four populations of the southeastern region of Brazil (São Paulo, Rio de Janeiro, Vitória and Belo Horizonte). No deviations from the Hardy–Weinb...

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Bibliographic Details
Published in:International journal of legal medicine 2010-09, Vol.124 (5), p.427-432
Main Authors: Martins, Joyce A., Costa, Jeane C., Paneto, Greiciane G., Figueiredo, Raquel F., Gusmão, Leonor, Sánchez-Diz, Paula, Carracedo, Ángel, Cicarelli, Regina M. B.
Format: Article
Language:English
Subjects:
Brazil
Chromosomes, Human, X
Collaboration
DNA Fingerprinting
Equilibrium
Female
Forensic Medicine
Gene Frequency
Genetic testing
Genetic Variation
Genetics, Population
Humans
Linkage Disequilibrium
Male
Males
Medical Law
Medicine
Medicine & Public Health
Mitochondrial DNA
Original Article
Polymerase Chain Reaction
Software
Tandem Repeat Sequences
Women
Working groups
Y chromosomes
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Summary:Ten X-chromosomal short tandem repeats (DXS8378, DXS9902, DXS7132, DXS9898, DXS6809, DXS6789, DXS7133, GATA172D05, GATA31E08 and DXS7423) were analyzed in four populations of the southeastern region of Brazil (São Paulo, Rio de Janeiro, Vitória and Belo Horizonte). No deviations from the Hardy–Weinberg equilibrium were observed for any of the analyzed loci in the four populations. The average diversity per locus varied between 68% for DXS8378, DXS7133, and DXS7423 and 83%, for DXS6809, with Rio de Janeiro being the most diverse population. Overall power of discrimination values in females varied between 0.99999999990 and 0.99999999997 and between 0.9999991 and 0.9999995 in males. These high values show the potential of this system for forensic application and relationships' testing in the studied groups. Genetic comparisons (exact tests of population differentiation and pairwise genetic distances) revealed significant differences between Brazilian and other populations from Europe, Latin America and Africa, as well as among different Brazilian populations.
ISSN:0937-9827
1437-1596
DOI:10.1007/s00414-010-0478-9