Role of Glycogen in Processes of Cerebellar Glial Cells under Conditions of Its Damage with Sodium Nitrite

Ultrastructure of processes of glial cell, astrocytes of the molecular layer of cerebellar cortex in Rana temporaria frog, under conditions of damage to the cerebellum caused by NO-generating compound sodium nitrite was studied under an electron microscope. It is found that astrocytes have at least...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2010-12, Vol.150 (2), p.247-250
Main Authors: Samosudova, N. V, Reutov, V. P, Larionova, N. P
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell Surface Extensions - drug effects
Cell Surface Extensions - metabolism
Cell Surface Extensions - ultrastructure
cerebellum
Cerebellum - cytology
Cerebellum - metabolism
glial processes
Glucose metabolism
Glycogen
Glycogen - metabolism
Internal Medicine
Laboratory Medicine
Male
Microscopy, Electron
Morphology and Pathomorphology
Neuroglia - drug effects
Neuroglia - metabolism
neuron
Nitric Oxide - toxicity
Pathology
Rana temporaria
Rana temporaria - metabolism
sodium nitrite
Sodium Nitrite - toxicity
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Summary:Ultrastructure of processes of glial cell, astrocytes of the molecular layer of cerebellar cortex in Rana temporaria frog, under conditions of damage to the cerebellum caused by NO-generating compound sodium nitrite was studied under an electron microscope. It is found that astrocytes have at least two types of processes: the first (fibrillar) primarily contained numerous fibrils and few glycogen granules and the second (granular) primarily containing glycogen granules. In the presence of NO-generating compound in toxic doses, fibrillar processes are damaged or completely degrade more rapidly than granular ones. The processes containing glycogen can protect both damaged synapses and individual synaptic buttons by forming a compact structure, wrapping, around them. We analyzed the possible role of glycogen of cerebellar glial cell processes in neuroglial interactions in the presence of sodium nitrite.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-010-1116-8