Relationship between double product break point, lactate threshold, and ventilatory threshold in cardiac patients

A double product break point (DPBP) occurs simultaneously with both ventilatory threshold (VT) and lactate threshold (LT) in normal subjects. We sought to determine whether a DPBP also occurs in cardiac patients and to investigate correlations between DPBP, VT and LT (study 1). We also evaluated a n...

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Bibliographic Details
Published in:European journal of applied physiology 2004-03, Vol.91 (2-3), p.224-229
Main Authors: Omiya, Kazuto, Itoh, Haruki, Harada, Naomi, Maeda, Tomoko, Tajima, Akihiko, Oikawa, Keiko, Koike, Akira, Aizawa, Tadanori, Fu, Long-Tai, Osada, Naohiko
Format: Article
Language:English
Subjects:
Adult
Anaerobic Threshold
Blood Pressure
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - physiopathology
Exercise Test - methods
Female
Heart Rate
Humans
Lactic Acid - blood
Male
Medical research
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Statistics as Topic
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Summary:A double product break point (DPBP) occurs simultaneously with both ventilatory threshold (VT) and lactate threshold (LT) in normal subjects. We sought to determine whether a DPBP also occurs in cardiac patients and to investigate correlations between DPBP, VT and LT (study 1). We also evaluated a non-invasive DPBP measurement system that determined blood pressure automatically by the cuff method (study 2). Study 1 comprised 15 patients [8 men and 7 women, mean (SD) age 47.7 (11.1) years] who performed cardiopulmonary exercise tests on a cycle ergometer. The double product was defined as the product of heart rate and direct systolic blood pressure. Arterial blood samples were obtained for measurement of lactate, pyruvate, pH, and norepinephrine levels. VT was determined by gas analysis, and LT was determined as the lactate/pyruvate ratio. DPBPs were detected in all 15 patients. Double product slopes above the DPBP were significantly greater than those below the DPBP (286.2 vs 98.5/W, P
ISSN:1439-6319
1439-6327
DOI:10.1007/s00421-003-0959-3