Black brain: transformation of a melanocytoma with diffuse melanocytosis into a primary cerebral melanoma

We describe here a rare case of the transformation of a supratentorial melanocytoma and diffuse melanocytosis into a primary malignant, CNS melanoma. A 71-year-old woman was admitted after suffering from bulbar speech and dysfunction of fine motor skills for three years. Cerebral imaging revealed an...

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Bibliographic Details
Published in:Journal of neuro-oncology 2011-04, Vol.102 (2), p.323-328
Main Authors: Gempt, Jens, Buchmann, Niels, Grams, Astrid E., Zoubaa, Saida, Schlegel, Jürgen, Meyer, Bernhard, Ringel, Florian
Format: Article
Language:English
Subjects:
Aged
Brain Neoplasms - pathology
Brain Neoplasms - surgery
Case Report
Craniotomy
Female
Humans
Magnetic Resonance Imaging
Medicine
Medicine & Public Health
Melanoma - pathology
Melanoma - surgery
Neurology
Nevus, Pigmented - pathology
Nevus, Pigmented - surgery
Oncology
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Summary:We describe here a rare case of the transformation of a supratentorial melanocytoma and diffuse melanocytosis into a primary malignant, CNS melanoma. A 71-year-old woman was admitted after suffering from bulbar speech and dysfunction of fine motor skills for three years. Cerebral imaging revealed an inhomogeneous tumor mass in the right frontal lobe. After craniotomy and opening of the dura, a partially black brain surface was exposed. The solid tumor mass was completely resected. Histopathological workup of the surgical specimen (solid tumor) revealed a melanocytoma with transformation into a malignant melanoma. Three months after surgery, an MR scan was carried out, revealing local tumor recurrence and intracranial spreading. At this time the patient agreed to undergo whole brain radiation therapy, which was carried out. At this date patient has survived 18 months since primary diagnosis with progressive neurological symptoms.
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-010-0311-9