Anaphylactic reaction after fluorescein sodium administration during intracranial surgery

Abstract We present a male patient who underwent a fluorescein sodium-guided brain tumor excision and experienced an anaphylactic reaction with severe hypotension and bradycardia. A 54-year-old, 70 kg man of American Society of Anesthesiologists status II was seen with a history of glioma. In the 80...

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Bibliographic Details
Published in:Journal of clinical neuroscience 2011-03, Vol.18 (3), p.430-431
Main Authors: Dilek, Ozdamar, Ihsan, Anik, Tulay, Hosten
Format: Article
Language:English
Subjects:
Anaphylactic reaction
Anaphylaxis - chemically induced
Brain Neoplasms - surgery
Fluorescein - adverse effects
Fluorescein sodium
Fluorescent Dyes - adverse effects
Glioma - surgery
Humans
Male
Middle Aged
Neurology
Neurosurgical Procedures
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Summary:Abstract We present a male patient who underwent a fluorescein sodium-guided brain tumor excision and experienced an anaphylactic reaction with severe hypotension and bradycardia. A 54-year-old, 70 kg man of American Society of Anesthesiologists status II was seen with a history of glioma. In the 80th minute of the operation, 20 mg/kg intravenous (i.v.) fluorescein sodium was injected after dural opening. A few minutes later, the anaphylactic reaction was diagnosed. Surgery was ended and the patient was delivered to the intensive care unit with intubation. Laboratory values were: immunoglobulin E, 332 U (upper limit 100 U); and elevated tryptase, 3.12 mg/dL. In view of the expanding use of fluorescein sodium in clinical procedures, physicians should be alerted to this rare but life-threatening adverse event.
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2010.06.012