Axial and total-body bone densitometry using a narrow-angle fan-beam

• Published in: Osteoporosis international 2000-02, Vol.11 (2), p.158-166
• Main Authors: MAZESS, R. B, HANSON, J. A, PAYNE, R, NORD, R, WILSON, M
• Format: Article
• Language: English
• Subjects: Absorptiometry, Photon - instrumentation; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Bone Density; Calibration; Energy; Evaluation Studies as Topic; Femur - diagnostic imaging; Femur - physiology; Humans; Investigative techniques, diagnostic techniques (general aspects); Medical sciences; Middle Aged; Osteoarticular system. Muscles; Osteoporosis; Prodigies; Radiation; Radiation Dosage; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Sensors; Spine - diagnostic imaging; Spine - physiology; Time Factors; Zinc telluride
• ISSN: 0937-941X; 1433-2965
• DOI: 10.1007/PL00004178

We assessed a new dual-energy bone densitometer, the PRODIGY, that uses a narrow-angle fan-beam (4.5 degrees) oriented parallel to the longitudinal axis of the body (i.e., perpendicular to the usual orientation). High-resolution scans across the body can be stepped at 17 mm intervals. The energy-sensitive array detector uses cadmium zinc telluride, which allowed rapid photon counting. Spine and femur scans required 30 s, and total-body scans required 4-5 min; the dose was only 3.7 mrem and 0.04 mrem respectively, or about 5 to 10 times lower than conventional fan-beam densitometry. We found only a small influence of soft-tissue thickness on bone mineral density (BMD) results. There was also a small (+/- 1%) influence of height above the tabletop on BMD results. A software correction for object height allowed a first-order correction for the large magnification effects of position on bone mineral content (BMC) and area. Consequently, the results for BMC and area, as well as BMD, with PRODIGY corresponded closely to those obtained using the predecessor DPX densitometer, both in vitro and in vivo; there was a generally high correlation (r = 0.98-0.99) for BMD values. Spine and femur values for BMC, area and BMD averaged within 0.5% in vivo (n = 122), as did total-body BMC and BMD (n = 46). PRODIGY values for total-body lean tissue and fat also corresponded within 1% to DPX values. Regional and total-body BMD were measured with 0.5% precision in vitro and 1% precision in vivo. The new PRODIGY densitometer appears to combine the low dose and high accuracy of pencil-beam densitometry with the speed of fan-beam densitometers.