Relationship between disease activity and serum levels of vitamin D metabolites and parathyroid hormone in ankylosing spondylitis

Vertebral fractures due to osteoporosis are a common but frequently unrecognized complication of ankylosing spondylitis (AS) and various factors may contribute to the development of osteoporosis in AS. It is known that inflammatory activity in rheumatic disease (i.e., proinflammatory cytokines) itse...

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Bibliographic Details
Published in:Osteoporosis international 2001-12, Vol.12 (12), p.1031-1035
Main Authors: Lange, U, Jung, O, Teichmann, J, Neeck, G
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Alkaline Phosphatase - blood
Arthritis
Bone Remodeling
Creatinine
Cytokines
Female
Humans
Male
Metabolism
Metabolites
Middle Aged
Osteoporosis
Osteoporosis - etiology
Parathyroid Hormone - blood
Pathophysiology
Phosphatase
Pyridinium Compounds - urine
Rheumatology
Severity of Illness Index
Spondylitis, Ankylosing - blood
Spondylitis, Ankylosing - complications
Spondylitis, Ankylosing - physiopathology
Steroid Hydroxylases - blood
Vitamin D
Vitamin D - metabolism
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Summary:Vertebral fractures due to osteoporosis are a common but frequently unrecognized complication of ankylosing spondylitis (AS) and various factors may contribute to the development of osteoporosis in AS. It is known that inflammatory activity in rheumatic disease (i.e., proinflammatory cytokines) itself plays a possible role in the pathophysiology of bone loss. 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) seems to be another possible candidate for mediatory function in regulating both the inflammatory process and bone turnover. The aim of this study was to evaluate the relation between disease activity, bone turnover and calciotropic hormones. In 70 patients with established AS and an age- and sex-matched control group, the relation between disease activity (erythrocyte sedimentation rate, C-reactive protein, Bath Ankylosing Spondylitis Disease Activity Index), and serum levels of vitamin D metabolites, parathyroid hormone (PTH), bone alkaline phosphatase (bAP) and urinary pyridinium cross-links were determined. Serum levels of 1,25(OH)2D3 (p
ISSN:0937-941X
1433-2965
DOI:10.1007/s001980170013