Oral administration of coenzyme Q sub(10) reduces MPTP-induced loss of dopaminergic nerve terminals in the striatum in mice

The neuroprotective effect of coenzyme Q sub(10) (CoQ sub(10)) has been reported in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. In this study, we investigated whether oral administration of CoQ sub(10) could protect the striatal dopaminergic (DAergic) nerve terminals against MP...

Full description

Saved in:
Bibliographic Details
Published in:Neurological sciences 2012-02, Vol.33 (1), p.195-199
Main Authors: Kobayashi, Shota, Muroyama, Akiko, Matsushima, Hiroaki, Yoshimura, Ikuo, Mitsumoto, Yasuhide
Format: Article
Language:English
Subjects:
Actin
Coenzyme Q10
Dopamine
Dopamine transporter
MPTP
Neostriatum
Nerve endings
Neurodegeneration
Neuroprotection
Oral administration
Synaptophysin
Synaptosomes
Toxicity
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The neuroprotective effect of coenzyme Q sub(10) (CoQ sub(10)) has been reported in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. In this study, we investigated whether oral administration of CoQ sub(10) could protect the striatal dopaminergic (DAergic) nerve terminals against MPTP-induced toxicity in C57BL/6N mice using immunoisolation technique for DAergic synaptosomes. CoQ sub(10) significantly attenuated decrease in dopamine transporter as well as in synaptophysin and actin protein levels in DAergic synaptosomes from MPTP-treated mice. The effect of CoQ sub(10) was also observed in crude synaptosomes fraction, but not in homogenate. Our results indicate that the nerve terminals are a site for the action of CoQ sub(10) against the MPTP-induced DAergic neurodegeneration.
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-011-0627-z