Prophylactic use of antibiotic-loaded bone cement in primary total knee replacement

Despite significant advances in intraoperative antimicrobial procedures, deep infection remains the most devastating complication following total joint arthroplasty. Clinical studies’ results and safety profile of antibiotic-loaded bone cement are discussed in this review. Antibiotic bone cement pro...

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Bibliographic Details
Published in:Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA sports traumatology, arthroscopy : official journal of the ESSKA, 2010-02, Vol.18 (2), p.181-186
Main Authors: Randelli, Pietro, Evola, Francesco R., Cabitza, Paolo, Polli, Luca, Denti, Matteo, Vaienti, Luca
Format: Article
Language:English
Subjects:
Antibiotic Prophylaxis
Antibiotics
Arthroplasty, Replacement, Knee
Bone Cements - chemistry
Bone Cements - therapeutic use
Bones
Disease prevention
Drug Carriers - therapeutic use
Drug dosages
Drug resistance
Europe
Humans
Infection
Infections
Joint replacement surgery
Joints
Knee
Knees
Mechanical properties
Medicine
Medicine & Public Health
Orthopedics
Polymethyl methacrylate
Prostheses
Prosthesis-Related Infections - prevention & control
Safety
Sports
Strategy
Surgery
Toxicity
Transplants & implants
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Summary:Despite significant advances in intraoperative antimicrobial procedures, deep infection remains the most devastating complication following total joint arthroplasty. Clinical studies’ results and safety profile of antibiotic-loaded bone cement are discussed in this review. Antibiotic bone cement prophylaxis is a safe and effective strategy in reducing the risk of deep infection following primary total joint arthroplasty.
ISSN:0942-2056
1433-7347
DOI:10.1007/s00167-009-0921-y