Acute hypersensitive-like injury in specific-pathogen-free chickens after infection with very virulent infectious bursal disease virus

Very virulent infectious bursal disease virus (vvIBDV) can cause systemic inflammatory syndromes and acute death in specific-pathogen-free chickens within 72 h. However, the subtle mechanism of these severe inflammatory responses has been unsatisfactorily resolved until now. This study determined th...

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Bibliographic Details
Published in:Poultry science 2012-02, Vol.91 (2), p.334-339
Main Authors: Wang, D, Jia, X, She, R, Liu, Y
Format: Article
Language:English
Subjects:
Animals
Birnaviridae Infections - pathology
Birnaviridae Infections - veterinary
Birnaviridae Infections - virology
Bursa of Fabricius
Chemokines - genetics
Chemokines - metabolism
Chickens
Eosinophil Major Basic Protein - genetics
Eosinophil Major Basic Protein - metabolism
Eosinophils - metabolism
Gastric Mucosa - metabolism
Gene Expression Regulation - immunology
Infectious bursal disease virus
Infectious bursal disease virus - pathogenicity
Kidney - metabolism
Lung - metabolism
Mast Cells - metabolism
Poultry Diseases - pathology
Poultry Diseases - virology
Specific Pathogen-Free Organisms
Spleen - metabolism
Systemic Inflammatory Response Syndrome - veterinary
Thymus Gland - metabolism
Tryptases - metabolism
Virulence
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Summary:Very virulent infectious bursal disease virus (vvIBDV) can cause systemic inflammatory syndromes and acute death in specific-pathogen-free chickens within 72 h. However, the subtle mechanism of these severe inflammatory responses has been unsatisfactorily resolved until now. This study determined the kinetics of mast cells, tryptase, eosinophilic major basic protein, and eotaxin expression in specific-pathogen-free chickens after vvIBDV infection. Results showed that mast cell population, tryptase activity, major basic protein, and eotaxin expression were increased markedly in the vvIBDV-infected animals compared with the controls, with a significant difference in the bursa. Acute inflammatory lesions and high mortality were observed in vvIBDV-infected chickens. These observations implicate activated mast cells and eosinophils as important participants in vvIBDV-induced acute inflammatory lesions through mediators released in a short timeframe.
ISSN:0032-5791
DOI:10.3382/ps.2010-01203