Altered Response to DEET Repellent After Infection of Aedes aegypti (Diptera: Culicidae) with Sindbis Virus

To determine whether a Sindbis virus (family Togaviridae, genus Alphavirus, SINV) infection in Aedes aegypti (L.) (Diptera: Culicidae) affected its response to the repellent DEET, we orally exposed Ae. aegypti to an artificial bloodmeal containing SINV or diluent and then allowed to feed on a 10% su...

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Bibliographic Details
Published in:Journal of medical entomology 2011-11, Vol.48 (6), p.1226-1230
Main Authors: Qualls, Whitney A., Day, Jonathan F., Xue, Rui-De, Bowers, Doria F.
Format: Article
Language:English
Subjects:
Aedes - virology
Aedes aegypti
Alphavirus
Animals
arbovirus
behavior
Biological and medical sciences
Culicidae
DEET
Diptera
dissemination
Feeding Behavior
Female
Fundamental and applied biological sciences. Psychology
Health aspects
Infection
Insect Repellents
Insecta
Invertebrates
Legal fees
legs
Medically important nuisances and vectors, pests of stored products and materials: population survey and control
olfaction
Sindbis Virus
sucrose
Togaviridae
VECTOR-BORNE DISEASES, SURVEILLANCE, PREVENTION
Vectors. Intermediate hosts
viruses
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Summary:To determine whether a Sindbis virus (family Togaviridae, genus Alphavirus, SINV) infection in Aedes aegypti (L.) (Diptera: Culicidae) affected its response to the repellent DEET, we orally exposed Ae. aegypti to an artificial bloodmeal containing SINV or diluent and then allowed to feed on a 10% sucrose suspension containing 3% DEET. When tested seven or more days after the initial bloodmeal, although none of the diluent-exposed mosquitoes fed on the DEET-sucrose suspension, at least 60% of the SINV-exposed mosquitoes fed on the suspension. When legs from the SINV-exposed mosquitoes were tested to determine dissemination status, 89% of those that fed on the DEET-sucrose suspension contained virus. In contrast, only 34% of the nonfeeders had a disseminated infection. When offered a choice between sucrose with or without DEET, a significantly higher percentage of the SINV-exposed mosquitoes than the control mosquitoes fed on the sucrose containing 3% DEET. Together, these results indicate that mosquitoes with a disseminated SINV infection may be less responsive to DEET than uninfected mosquitoes. Therefore, repellent use may be less effective in deterring infected mosquitoes from biting than previously believed.
ISSN:0022-2585
1938-2928
0022-2585
DOI:10.1603/ME10163