Sleep deprivation prevents stimulation-induced increases of levels of P-CREB and BDNF: Protection by caffeine

It is well known that caffeine and sleep deprivation have opposing effects on learning and memory; therefore, this study was undertaken to determine the effects of chronic (4 wks) caffeine treatment (0.3 g/l in drinking water) on long-term memory deficit associated with 24 h sleep deprivation. Anima...

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Bibliographic Details
Published in:Molecular and cellular neuroscience 2011-04, Vol.46 (4), p.742-751
Main Authors: Alhaider, Ibrahim A., Aleisa, Abdulaziz M., Tran, Trinh T., Alkadhi, Karim A.
Format: Article
Language:English
Subjects:
Animals
Brain - drug effects
Brain - metabolism
Brain-Derived Neurotrophic Factor - metabolism
CA1 area
Caffeine
Caffeine - pharmacology
Cyclic AMP Response Element-Binding Protein - genetics
Cyclic AMP Response Element-Binding Protein - metabolism
Hippocampus - drug effects
Hippocampus - metabolism
Humans
Lat-long-term potentiation
Long-Term Potentiation - drug effects
Long-Term Potentiation - physiology
Male
Memory - drug effects
Memory Disorders - etiology
P-CREB
Phosphorylation
Rats
Rats, Wistar
Sleep deprivation
Sleep Deprivation - complications
Sleep Deprivation - physiopathology
Spatial memory
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Summary:It is well known that caffeine and sleep deprivation have opposing effects on learning and memory; therefore, this study was undertaken to determine the effects of chronic (4 wks) caffeine treatment (0.3 g/l in drinking water) on long-term memory deficit associated with 24 h sleep deprivation. Animals were sleep deprived using the modified multiple platform method. The results showed that chronic caffeine treatment prevented the impairment of long-term memory as measured by performance in the radial arm water maze task and normalized L-LTP in area CA1 of the hippocampi of sleep-deprived anesthetized rats. Sleep deprivation prevents the high frequency stimulation-induced increases in the levels of phosphorylated-cAMP response element binding protein (P-CREB) and brain-derived neurotrophic factor (BDNF) seen during the expression of late phase long-term potentiation (L-LTP). However, chronic caffeine treatment prevented the effect of sleep-deprivation on the stimulated levels of P-CREB and BDNF. The results suggest that chronic caffeine treatment may protect the sleep-deprived brain probably by preserving the levels of P-CREB and BDNF.
ISSN:1044-7431
1095-9327
DOI:10.1016/j.mcn.2011.02.006