A case of resectable lung adenocarcinoma associated with sarcoidosis

A 71-year-old woman with uveitis was referred to our hospital for further examination of the possible underlying diseases. In roentgenological examination with plain X-ray and CT scan, hilar and mediastinal lymphadenopathy and a mass shadow in the right upper lung field was observed, whereas fibroti...

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Bibliographic Details
Published in:Cancer Immunology, Immunotherapy Immunotherapy, 1999-09, Vol.16 (3), p.216-220
Main Authors: YANAGAWA, H, GOTO, H, MANIWA, K, OGUSHI, F, TAKAHASHI, K, MONDEN, Y, HIROSE, T, SANO, N, SONE, S
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - complications
Adenocarcinoma - diagnostic imaging
Adenocarcinoma - pathology
Aged
Alveoli
Biological and medical sciences
Biopsy
Bronchoscopes
Bronchus
CD4 antigen
Computed tomography
Data processing
Female
Fiberoptics
Granulomatosis
Hospitals
Humans
Immunotherapy
Ionizing radiation
Literature reviews
Lung
Lung cancer
Lung Neoplasms - complications
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - pathology
Lymphadenopathy
Lymphatic Diseases
Lymphocytes
Medical sciences
Oncology
Pneumology
Pneumonia
Radiography
Sarcoidosis
Sarcoidosis, Pulmonary - complications
Sarcoidosis, Pulmonary - diagnostic imaging
Sarcoidosis, Pulmonary - pathology
Tumors of the respiratory system and mediastinum
Uveitis
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Summary:A 71-year-old woman with uveitis was referred to our hospital for further examination of the possible underlying diseases. In roentgenological examination with plain X-ray and CT scan, hilar and mediastinal lymphadenopathy and a mass shadow in the right upper lung field was observed, whereas fibrotic changes were not obvious in both lung fields. Transbronchial lung biopsy with fiberoptic bronchoscope revealed granulomatous interstitial pneumonia. CD4-positive lymphocytes were increased in bronchoalveolar lavage. The patient was diagnosed as having sarcoidosis. Subsequently, right upper lobectomy was performed, and Stage I lung adenocarcinoma was diagnosed. The patient is under follow up without medication and the disease has been stable for two years. A relationship between epithelioid granulomatosis and malignant diseases is discussed and a review of the literature is given. Since it is still controversial as to the incidence of malignant diseases in sarcoidosis patients, it is important to accumulate data on these associations.
ISSN:1357-0560
0340-7004
1559-131X
1432-0851
DOI:10.1007/BF02906135