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Influence of Cell Quality on Clinical Outcome After Autologous Chondrocyte Implantation
Background: Several factors influence clinical outcome after autologous chondrocyte implantation (ACI) for the treatment of cartilage defects of the knee joint. Hypothesis/Purpose: The aim of the present study was to investigate the influence of cell quality on clinical outcome after ACI. The hypoth...
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| Published in: | The American journal of sports medicine 2012-03, Vol.40 (3), p.556-561 |
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| container_end_page | 561 |
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| container_title | The American journal of sports medicine |
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| creator | Niemeyer, Philipp Pestka, Jan M. Salzmann, Gian M. Südkamp, Norbert P. Schmal, Hagen |
| description | Background: Several factors influence clinical outcome after autologous chondrocyte implantation (ACI) for the treatment of cartilage defects of the knee joint.
Hypothesis/Purpose: The aim of the present study was to investigate the influence of cell quality on clinical outcome after ACI. The hypothesis of the authors was that cell quality at the time of transplantation influences clinical outcome after ACI for cartilage defects.
Study Design: Cohort study; Level of evidence, 3.
Methods: A total of 80 patients were included in the present study. Knee function was assessed before surgery as well as 6, 12, and 24 months after ACI using standard instruments (International Knee Documentation Committee [IKDC], Lysholm, and Tegner scores). Cell quality was evaluated by determination of antigen expression of CD44 expression, aggrecan, collagen type II, and cell viability. A linear regression analysis including preoperative knee function, defect size, defect location, defect origin, body mass index, patient age, and other parameters was performed to evaluate the influence of these parameters on postoperative knee function.
Results: Preoperative IKDC score increased from 49.6 ± 13.8 points to 75.5 ± 14.6 points at 24 months (P < .05). Postoperative IKDC score at 6, 12, and 24 months was significantly influenced by collagen type II expression, CD44 expression, and cell viability (all P < .05). No correlation between aggrecan and outcome was found. Quantitative influence of individual factors differed between different time points.
Conclusion: Cell quality seems to be one of many factors that influences clinical outcome after ACI in patients with cartilage defects of the knee joint. It constitutes one aspect among various others affecting clinical outcome. |
| doi_str_mv | 10.1177/0363546511428879 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_954661366</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0363546511428879</sage_id><sourcerecordid>926646515</sourcerecordid><originalsourceid>FETCH-LOGICAL-c425t-f0225b7d2f96957f24ea9b252ebcc5598df23da7baa385ed854eff8141eefd03</originalsourceid><addsrcrecordid>eNqFkc1r3DAQxUVpaTZp7z0VUSg5udGHJdnHxTTpQiAUAjkaWR6lDrK0leTD_veR2W0DgdLTHOY3b-bNQ-gTJd8oVeqKcMlFLQWlNWsa1b5BGyoEqziX4i3arO1q7Z-h85SeCCFUyeY9OmOMqprXbIMedt66BbwBHCzuwDn8c9FuygccPO7c5CejHb5bsgkz4K3NEPF2ycGFx7Ak3P0KfozBHDLg3bx32medp-A_oHdWuwQfT_UC3V9_v-9-VLd3N7tue1uZmolcWcKYGNTIbCtboSyrQbcDEwwGY4Rom9EyPmo1aM0bAWMjarC2oTUFsCPhF-jyKLuP4fcCKffzlExxoT2U8_q2uJeUS_l_kkm5flIU8ssr8iks0RcXBVKUNbRdIXKETAwpRbD9Pk6zjoeekn7Npn-dTRn5fNJdhhnGvwN_wijA1xOgU3m6jdqbKb1wQrGitQpVRy7pR3g57p-LnwFn8KLI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>927128195</pqid></control><display><type>article</type><title>Influence of Cell Quality on Clinical Outcome After Autologous Chondrocyte Implantation</title><source>EBSCOhost SPORTDiscus with Full Text</source><source>SAGE</source><creator>Niemeyer, Philipp ; Pestka, Jan M. ; Salzmann, Gian M. ; Südkamp, Norbert P. ; Schmal, Hagen</creator><creatorcontrib>Niemeyer, Philipp ; Pestka, Jan M. ; Salzmann, Gian M. ; Südkamp, Norbert P. ; Schmal, Hagen</creatorcontrib><description>Background: Several factors influence clinical outcome after autologous chondrocyte implantation (ACI) for the treatment of cartilage defects of the knee joint.
Hypothesis/Purpose: The aim of the present study was to investigate the influence of cell quality on clinical outcome after ACI. The hypothesis of the authors was that cell quality at the time of transplantation influences clinical outcome after ACI for cartilage defects.
Study Design: Cohort study; Level of evidence, 3.
Methods: A total of 80 patients were included in the present study. Knee function was assessed before surgery as well as 6, 12, and 24 months after ACI using standard instruments (International Knee Documentation Committee [IKDC], Lysholm, and Tegner scores). Cell quality was evaluated by determination of antigen expression of CD44 expression, aggrecan, collagen type II, and cell viability. A linear regression analysis including preoperative knee function, defect size, defect location, defect origin, body mass index, patient age, and other parameters was performed to evaluate the influence of these parameters on postoperative knee function.
Results: Preoperative IKDC score increased from 49.6 ± 13.8 points to 75.5 ± 14.6 points at 24 months (P < .05). Postoperative IKDC score at 6, 12, and 24 months was significantly influenced by collagen type II expression, CD44 expression, and cell viability (all P < .05). No correlation between aggrecan and outcome was found. Quantitative influence of individual factors differed between different time points.
Conclusion: Cell quality seems to be one of many factors that influences clinical outcome after ACI in patients with cartilage defects of the knee joint. It constitutes one aspect among various others affecting clinical outcome.</description><identifier>ISSN: 0363-5465</identifier><identifier>EISSN: 1552-3365</identifier><identifier>DOI: 10.1177/0363546511428879</identifier><identifier>PMID: 22174342</identifier><identifier>CODEN: AJSMDO</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adolescent ; Adult ; Aggrecans - biosynthesis ; Biological and medical sciences ; Cartilage ; Cartilage, Articular - injuries ; Cartilage, Articular - surgery ; Cell Survival - physiology ; Cells ; Chondrocytes - transplantation ; Clinical outcomes ; Collagen ; Collagen Type II - biosynthesis ; Diseases of the osteoarticular system ; Female ; Humans ; Hyaluronan Receptors - biosynthesis ; Knee ; Knee - physiopathology ; Knee - surgery ; Male ; Medical sciences ; Orthopedic surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Transplantation, Autologous ; Transplants & implants ; Treatment Outcome ; Young Adult</subject><ispartof>The American journal of sports medicine, 2012-03, Vol.40 (3), p.556-561</ispartof><rights>2012 American Orthopaedic Society for Sports Medicine</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Sage Publications Ltd. Mar 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-f0225b7d2f96957f24ea9b252ebcc5598df23da7baa385ed854eff8141eefd03</citedby><cites>FETCH-LOGICAL-c425t-f0225b7d2f96957f24ea9b252ebcc5598df23da7baa385ed854eff8141eefd03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,79364</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25721429$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22174342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Niemeyer, Philipp</creatorcontrib><creatorcontrib>Pestka, Jan M.</creatorcontrib><creatorcontrib>Salzmann, Gian M.</creatorcontrib><creatorcontrib>Südkamp, Norbert P.</creatorcontrib><creatorcontrib>Schmal, Hagen</creatorcontrib><title>Influence of Cell Quality on Clinical Outcome After Autologous Chondrocyte Implantation</title><title>The American journal of sports medicine</title><addtitle>Am J Sports Med</addtitle><description>Background: Several factors influence clinical outcome after autologous chondrocyte implantation (ACI) for the treatment of cartilage defects of the knee joint.
Hypothesis/Purpose: The aim of the present study was to investigate the influence of cell quality on clinical outcome after ACI. The hypothesis of the authors was that cell quality at the time of transplantation influences clinical outcome after ACI for cartilage defects.
Study Design: Cohort study; Level of evidence, 3.
Methods: A total of 80 patients were included in the present study. Knee function was assessed before surgery as well as 6, 12, and 24 months after ACI using standard instruments (International Knee Documentation Committee [IKDC], Lysholm, and Tegner scores). Cell quality was evaluated by determination of antigen expression of CD44 expression, aggrecan, collagen type II, and cell viability. A linear regression analysis including preoperative knee function, defect size, defect location, defect origin, body mass index, patient age, and other parameters was performed to evaluate the influence of these parameters on postoperative knee function.
Results: Preoperative IKDC score increased from 49.6 ± 13.8 points to 75.5 ± 14.6 points at 24 months (P < .05). Postoperative IKDC score at 6, 12, and 24 months was significantly influenced by collagen type II expression, CD44 expression, and cell viability (all P < .05). No correlation between aggrecan and outcome was found. Quantitative influence of individual factors differed between different time points.
Conclusion: Cell quality seems to be one of many factors that influences clinical outcome after ACI in patients with cartilage defects of the knee joint. It constitutes one aspect among various others affecting clinical outcome.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aggrecans - biosynthesis</subject><subject>Biological and medical sciences</subject><subject>Cartilage</subject><subject>Cartilage, Articular - injuries</subject><subject>Cartilage, Articular - surgery</subject><subject>Cell Survival - physiology</subject><subject>Cells</subject><subject>Chondrocytes - transplantation</subject><subject>Clinical outcomes</subject><subject>Collagen</subject><subject>Collagen Type II - biosynthesis</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Humans</subject><subject>Hyaluronan Receptors - biosynthesis</subject><subject>Knee</subject><subject>Knee - physiopathology</subject><subject>Knee - surgery</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Orthopedic surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Transplantation, Autologous</subject><subject>Transplants & implants</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0363-5465</issn><issn>1552-3365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqFkc1r3DAQxUVpaTZp7z0VUSg5udGHJdnHxTTpQiAUAjkaWR6lDrK0leTD_veR2W0DgdLTHOY3b-bNQ-gTJd8oVeqKcMlFLQWlNWsa1b5BGyoEqziX4i3arO1q7Z-h85SeCCFUyeY9OmOMqprXbIMedt66BbwBHCzuwDn8c9FuygccPO7c5CejHb5bsgkz4K3NEPF2ycGFx7Ak3P0KfozBHDLg3bx32medp-A_oHdWuwQfT_UC3V9_v-9-VLd3N7tue1uZmolcWcKYGNTIbCtboSyrQbcDEwwGY4Rom9EyPmo1aM0bAWMjarC2oTUFsCPhF-jyKLuP4fcCKffzlExxoT2U8_q2uJeUS_l_kkm5flIU8ssr8iks0RcXBVKUNbRdIXKETAwpRbD9Pk6zjoeekn7Npn-dTRn5fNJdhhnGvwN_wijA1xOgU3m6jdqbKb1wQrGitQpVRy7pR3g57p-LnwFn8KLI</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Niemeyer, Philipp</creator><creator>Pestka, Jan M.</creator><creator>Salzmann, Gian M.</creator><creator>Südkamp, Norbert P.</creator><creator>Schmal, Hagen</creator><general>SAGE Publications</general><general>Sage Publications</general><general>Sage Publications Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Influence of Cell Quality on Clinical Outcome After Autologous Chondrocyte Implantation</title><author>Niemeyer, Philipp ; Pestka, Jan M. ; Salzmann, Gian M. ; Südkamp, Norbert P. ; Schmal, Hagen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-f0225b7d2f96957f24ea9b252ebcc5598df23da7baa385ed854eff8141eefd03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aggrecans - biosynthesis</topic><topic>Biological and medical sciences</topic><topic>Cartilage</topic><topic>Cartilage, Articular - injuries</topic><topic>Cartilage, Articular - surgery</topic><topic>Cell Survival - physiology</topic><topic>Cells</topic><topic>Chondrocytes - transplantation</topic><topic>Clinical outcomes</topic><topic>Collagen</topic><topic>Collagen Type II - biosynthesis</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Humans</topic><topic>Hyaluronan Receptors - biosynthesis</topic><topic>Knee</topic><topic>Knee - physiopathology</topic><topic>Knee - surgery</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Orthopedic surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Transplantation, Autologous</topic><topic>Transplants & implants</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Niemeyer, Philipp</creatorcontrib><creatorcontrib>Pestka, Jan M.</creatorcontrib><creatorcontrib>Salzmann, Gian M.</creatorcontrib><creatorcontrib>Südkamp, Norbert P.</creatorcontrib><creatorcontrib>Schmal, Hagen</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of sports medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Niemeyer, Philipp</au><au>Pestka, Jan M.</au><au>Salzmann, Gian M.</au><au>Südkamp, Norbert P.</au><au>Schmal, Hagen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Cell Quality on Clinical Outcome After Autologous Chondrocyte Implantation</atitle><jtitle>The American journal of sports medicine</jtitle><addtitle>Am J Sports Med</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>40</volume><issue>3</issue><spage>556</spage><epage>561</epage><pages>556-561</pages><issn>0363-5465</issn><eissn>1552-3365</eissn><coden>AJSMDO</coden><abstract>Background: Several factors influence clinical outcome after autologous chondrocyte implantation (ACI) for the treatment of cartilage defects of the knee joint.
Hypothesis/Purpose: The aim of the present study was to investigate the influence of cell quality on clinical outcome after ACI. The hypothesis of the authors was that cell quality at the time of transplantation influences clinical outcome after ACI for cartilage defects.
Study Design: Cohort study; Level of evidence, 3.
Methods: A total of 80 patients were included in the present study. Knee function was assessed before surgery as well as 6, 12, and 24 months after ACI using standard instruments (International Knee Documentation Committee [IKDC], Lysholm, and Tegner scores). Cell quality was evaluated by determination of antigen expression of CD44 expression, aggrecan, collagen type II, and cell viability. A linear regression analysis including preoperative knee function, defect size, defect location, defect origin, body mass index, patient age, and other parameters was performed to evaluate the influence of these parameters on postoperative knee function.
Results: Preoperative IKDC score increased from 49.6 ± 13.8 points to 75.5 ± 14.6 points at 24 months (P < .05). Postoperative IKDC score at 6, 12, and 24 months was significantly influenced by collagen type II expression, CD44 expression, and cell viability (all P < .05). No correlation between aggrecan and outcome was found. Quantitative influence of individual factors differed between different time points.
Conclusion: Cell quality seems to be one of many factors that influences clinical outcome after ACI in patients with cartilage defects of the knee joint. It constitutes one aspect among various others affecting clinical outcome.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>22174342</pmid><doi>10.1177/0363546511428879</doi><tpages>6</tpages></addata></record> |
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| ispartof | The American journal of sports medicine, 2012-03, Vol.40 (3), p.556-561 |
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| subjects | Adolescent Adult Aggrecans - biosynthesis Biological and medical sciences Cartilage Cartilage, Articular - injuries Cartilage, Articular - surgery Cell Survival - physiology Cells Chondrocytes - transplantation Clinical outcomes Collagen Collagen Type II - biosynthesis Diseases of the osteoarticular system Female Humans Hyaluronan Receptors - biosynthesis Knee Knee - physiopathology Knee - surgery Male Medical sciences Orthopedic surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Transplantation, Autologous Transplants & implants Treatment Outcome Young Adult |
| title | Influence of Cell Quality on Clinical Outcome After Autologous Chondrocyte Implantation |
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