Helicobacter pylori Infection and Colorectal Cancer Risk: Evidence From a Large Population-based Case-Control Study in Germany

Evidence concerning the role of Helicobacter pylori infection in the development of colorectal cancer remains controversial. The authors assessed the association of H. pylori seroprevalence with risk of colorectal cancer in a large population-based case-control study from Germany in 2003-2007. Serum...

Full description

Saved in:
Bibliographic Details
Published in:American journal of epidemiology 2012-03, Vol.175 (5), p.441-450
Main Authors: Zhang, Yan, Hoffmeister, Michael, Weck, Melanie N., Chang-Claude, Jenny, Brenner, Hermann
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antibodies, Bacterial - blood
Antigens, Bacterial - blood
Bacterial proteins
Bacterial Proteins - blood
Case-Control Studies
Colorectal cancer
Colorectal Neoplasms - microbiology
Enzyme-Linked Immunosorbent Assay
Female
Gram-negative bacteria
Helicobacter Infections - blood
Helicobacter Infections - complications
Helicobacter pylori
Helicobacter pylori - immunology
Humans
Logistic Models
Male
Middle Aged
Odds Ratio
Risk factors
Seroepidemiologic Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Evidence concerning the role of Helicobacter pylori infection in the development of colorectal cancer remains controversial. The authors assessed the association of H. pylori seroprevalence with risk of colorectal cancer in a large population-based case-control study from Germany in 2003-2007. Serum antibodies to H. pylori in general and the cytotoxin-associated gene A protein (CagA) were measured in 1,712 incident colorectal cancer cases and 1,669 controls. The association between H. pylori seroprevalence and colorectal cancer risk was estimated by logistic regression, with adjustment for potential confounders and stratification by age group, sex, anatomic subsites, and cancer stage. Overall, H. pylori seroprevalence was higher in cases (46.1%) than in controls (40.1%), resulting in an age- and sex-adjusted odds ratio of 1.30 (95% confidence interval (CI): 1.14, 1.50). Adjustment for established colorectal cancer risk factors decreased the odds ratio to 1.26 (95% CI: 1.09, 1.47), with a further reduction to 1.18 (95% CI: 1.01, 1.38) after additional adjustment for previous colorectal endoscopy. Stratified analyses showed risk elevation to be essentially confined to left-sided colorectal cancer, with an odds ratio of 1.22 (95% CI: 1.02, 1.45), suggesting that H. pylori infection may be associated with a small yet relevant risk increase in the left colorectum.
ISSN:0002-9262
1476-6256
DOI:10.1093/aje/kwr331