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A1/A2 polymorphism of the glycoprotein IIIa gene and diabetic retinopathy in Caucasians with type 2 diabetes
Background: A PlA1/A2 polymorphism of glycoprotein IIIa is known to be involved in the pathogenesis of arterial thrombosis, myocardial infarction, stroke and type 2 diabetes, but there is no evidence of association with diabetic retinopathy. The aim of this study was to examine the role of the PlA1...
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| Published in: | Clinical & experimental ophthalmology 2011-09, Vol.39 (7), p.665-672 |
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| container_title | Clinical & experimental ophthalmology |
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| creator | Nikolajevic-Starcevic, Jovana Petrovic, Mojca Globocnik Petrovic, Daniel |
| description | Background: A PlA1/A2 polymorphism of glycoprotein IIIa is known to be involved in the pathogenesis of arterial thrombosis, myocardial infarction, stroke and type 2 diabetes, but there is no evidence of association with diabetic retinopathy. The aim of this study was to examine the role of the PlA1/A2 polymorphism of the glycoprotein IIIa gene in the development of diabetic retinopathy in Caucasians with type 2 diabetes.
Design: Cross‐sectional case–control study.
Participants: Totally 222 patients with diabetic retinopathy and 120 diabetic subjects without clinical signs of diabetic retinopathy from the Eye Clinic, University Medical Centre Ljubljana were enrolled in the study.
Methods: Fundus examination and blood biochemical analysis were performed. The polymerase chain reaction and restriction fragment length polymorphism were used.
Main Outcome Measures: The total cholesterol, triglyceride, high‐density lipoprotein levels, fasting blood glucose and HbA1c were measured, and the genotypes of the PlA1/A2 polymorphism were determined.
Results: Patients with diabetic retinopathy had earlier onset, longer duration of type 2 diabetes and a higher incidence of insulin therapy compared to the diabetic patients without diabetic retinopathy. A significantly lower frequency of the A2A2 genotype of glycoprotein IIIa was found in diabetic patients with retinopathy compared to those without retinopathy (odds ratio = 0.49, 95% confidence interval = 0.28–0.89; P = 0.018).
Conclusions: The A2A2 genotype of the glycoprotein IIIa polymorphism was associated with lower risk for diabetic retinopathy in Caucasians with type 2 diabetes. Further studies are needed to elucidate its protective role in the development of diabetic retinopathy in Caucasians. |
| doi_str_mv | 10.1111/j.1442-9071.2011.02520.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_959137455</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3072398621</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4180-b9e3edb4b52b6d40c79a7e420683a64c8ec11d94a21aee1a7f6d13cd2cbe5f123</originalsourceid><addsrcrecordid>eNp9kUtv1DAURi0EoqXwF5AlFrBJ6utXkgWL0ahMRx3RBSAkNpbj3Ol4yIs4USf_vklnmAULvLCvdM_n1yGEAothGtf7GKTkUcYSiDkDiBlXnMWHF-Ty3Hh5qrVk8oK8CWHPGFNc6NfkgnOpuE7lJSkXcL3gtG3KsWq6dudDRZst7XdIH8rRNW3X9Ohrul6vLX3AGqmtC1p4m2PvHe2muW5a2-9GOlFLOzgbvK0DffT9jvZji5SfcAxvyautLQO-O61X5MeXm-_L22hzv1ovF5vISUhZlGcosMhlrniuC8lcktkEJWc6FVZLl6IDKDJpOVhEsMlWFyBcwV2OagtcXJGPx32n2_8ZMPSm8sFhWdoamyGYTGUgEqnURH76LwksE1IqofSEfvgH3TdDV0_vMCAF1yzVz0e_P1FDXmFh2s5XthvN3x-fgM9H4NGXOJ77wMxs1uzNLM3MAs1s1jybNQezvLmfqykfHfM-9Hg452332-hEJMr8_Loy335tVtkd4-ZWPAFhC6R_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1432608612</pqid></control><display><type>article</type><title>A1/A2 polymorphism of the glycoprotein IIIa gene and diabetic retinopathy in Caucasians with type 2 diabetes</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Nikolajevic-Starcevic, Jovana ; Petrovic, Mojca Globocnik ; Petrovic, Daniel</creator><creatorcontrib>Nikolajevic-Starcevic, Jovana ; Petrovic, Mojca Globocnik ; Petrovic, Daniel</creatorcontrib><description>Background: A PlA1/A2 polymorphism of glycoprotein IIIa is known to be involved in the pathogenesis of arterial thrombosis, myocardial infarction, stroke and type 2 diabetes, but there is no evidence of association with diabetic retinopathy. The aim of this study was to examine the role of the PlA1/A2 polymorphism of the glycoprotein IIIa gene in the development of diabetic retinopathy in Caucasians with type 2 diabetes.
Design: Cross‐sectional case–control study.
Participants: Totally 222 patients with diabetic retinopathy and 120 diabetic subjects without clinical signs of diabetic retinopathy from the Eye Clinic, University Medical Centre Ljubljana were enrolled in the study.
Methods: Fundus examination and blood biochemical analysis were performed. The polymerase chain reaction and restriction fragment length polymorphism were used.
Main Outcome Measures: The total cholesterol, triglyceride, high‐density lipoprotein levels, fasting blood glucose and HbA1c were measured, and the genotypes of the PlA1/A2 polymorphism were determined.
Results: Patients with diabetic retinopathy had earlier onset, longer duration of type 2 diabetes and a higher incidence of insulin therapy compared to the diabetic patients without diabetic retinopathy. A significantly lower frequency of the A2A2 genotype of glycoprotein IIIa was found in diabetic patients with retinopathy compared to those without retinopathy (odds ratio = 0.49, 95% confidence interval = 0.28–0.89; P = 0.018).
Conclusions: The A2A2 genotype of the glycoprotein IIIa polymorphism was associated with lower risk for diabetic retinopathy in Caucasians with type 2 diabetes. Further studies are needed to elucidate its protective role in the development of diabetic retinopathy in Caucasians.</description><identifier>ISSN: 1442-6404</identifier><identifier>EISSN: 1442-9071</identifier><identifier>DOI: 10.1111/j.1442-9071.2011.02520.x</identifier><identifier>PMID: 22452684</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Aged ; Alleles ; Biochemical analysis ; Blood ; Blood Glucose - metabolism ; Case-Control Studies ; Cholesterol ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Confidence intervals ; Cross-Sectional Studies ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - genetics ; Diabetic retinopathy ; Diabetic Retinopathy - blood ; Diabetic Retinopathy - genetics ; European Continental Ancestry Group - genetics ; Eye ; Fasting ; Female ; Gene polymorphism ; genetic risk factor ; Genotype ; Glucose ; Glycated Hemoglobin A - metabolism ; glycoprotein IIIa PlA1/A2 polymorphism ; Glycoproteins ; Heart attacks ; Humans ; Insulin ; Integrin beta3 - genetics ; Lipoproteins ; Male ; Middle Aged ; Myocardial infarction ; Ophthalmology ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide - genetics ; Restriction fragment length polymorphism ; Retinopathy ; Risk Factors ; Stroke ; Thrombosis ; Triglycerides ; Triglycerides - blood</subject><ispartof>Clinical & experimental ophthalmology, 2011-09, Vol.39 (7), p.665-672</ispartof><rights>2011 The Authors. Clinical and Experimental Ophthalmology © 2011 Royal Australian and New Zealand College of Ophthalmologists</rights><rights>2011 The Authors. Clinical and Experimental Ophthalmology © 2011 Royal Australian and New Zealand College of Ophthalmologists.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4180-b9e3edb4b52b6d40c79a7e420683a64c8ec11d94a21aee1a7f6d13cd2cbe5f123</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22452684$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nikolajevic-Starcevic, Jovana</creatorcontrib><creatorcontrib>Petrovic, Mojca Globocnik</creatorcontrib><creatorcontrib>Petrovic, Daniel</creatorcontrib><title>A1/A2 polymorphism of the glycoprotein IIIa gene and diabetic retinopathy in Caucasians with type 2 diabetes</title><title>Clinical & experimental ophthalmology</title><addtitle>Clin Exp Ophthalmol</addtitle><description>Background: A PlA1/A2 polymorphism of glycoprotein IIIa is known to be involved in the pathogenesis of arterial thrombosis, myocardial infarction, stroke and type 2 diabetes, but there is no evidence of association with diabetic retinopathy. The aim of this study was to examine the role of the PlA1/A2 polymorphism of the glycoprotein IIIa gene in the development of diabetic retinopathy in Caucasians with type 2 diabetes.
Design: Cross‐sectional case–control study.
Participants: Totally 222 patients with diabetic retinopathy and 120 diabetic subjects without clinical signs of diabetic retinopathy from the Eye Clinic, University Medical Centre Ljubljana were enrolled in the study.
Methods: Fundus examination and blood biochemical analysis were performed. The polymerase chain reaction and restriction fragment length polymorphism were used.
Main Outcome Measures: The total cholesterol, triglyceride, high‐density lipoprotein levels, fasting blood glucose and HbA1c were measured, and the genotypes of the PlA1/A2 polymorphism were determined.
Results: Patients with diabetic retinopathy had earlier onset, longer duration of type 2 diabetes and a higher incidence of insulin therapy compared to the diabetic patients without diabetic retinopathy. A significantly lower frequency of the A2A2 genotype of glycoprotein IIIa was found in diabetic patients with retinopathy compared to those without retinopathy (odds ratio = 0.49, 95% confidence interval = 0.28–0.89; P = 0.018).
Conclusions: The A2A2 genotype of the glycoprotein IIIa polymorphism was associated with lower risk for diabetic retinopathy in Caucasians with type 2 diabetes. Further studies are needed to elucidate its protective role in the development of diabetic retinopathy in Caucasians.</description><subject>Aged</subject><subject>Alleles</subject><subject>Biochemical analysis</subject><subject>Blood</subject><subject>Blood Glucose - metabolism</subject><subject>Case-Control Studies</subject><subject>Cholesterol</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Confidence intervals</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetic retinopathy</subject><subject>Diabetic Retinopathy - blood</subject><subject>Diabetic Retinopathy - genetics</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Eye</subject><subject>Fasting</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>genetic risk factor</subject><subject>Genotype</subject><subject>Glucose</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>glycoprotein IIIa PlA1/A2 polymorphism</subject><subject>Glycoproteins</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Insulin</subject><subject>Integrin beta3 - genetics</subject><subject>Lipoproteins</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial infarction</subject><subject>Ophthalmology</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Restriction fragment length polymorphism</subject><subject>Retinopathy</subject><subject>Risk Factors</subject><subject>Stroke</subject><subject>Thrombosis</subject><subject>Triglycerides</subject><subject>Triglycerides - blood</subject><issn>1442-6404</issn><issn>1442-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9kUtv1DAURi0EoqXwF5AlFrBJ6utXkgWL0ahMRx3RBSAkNpbj3Ol4yIs4USf_vklnmAULvLCvdM_n1yGEAothGtf7GKTkUcYSiDkDiBlXnMWHF-Ty3Hh5qrVk8oK8CWHPGFNc6NfkgnOpuE7lJSkXcL3gtG3KsWq6dudDRZst7XdIH8rRNW3X9Ohrul6vLX3AGqmtC1p4m2PvHe2muW5a2-9GOlFLOzgbvK0DffT9jvZji5SfcAxvyautLQO-O61X5MeXm-_L22hzv1ovF5vISUhZlGcosMhlrniuC8lcktkEJWc6FVZLl6IDKDJpOVhEsMlWFyBcwV2OagtcXJGPx32n2_8ZMPSm8sFhWdoamyGYTGUgEqnURH76LwksE1IqofSEfvgH3TdDV0_vMCAF1yzVz0e_P1FDXmFh2s5XthvN3x-fgM9H4NGXOJ77wMxs1uzNLM3MAs1s1jybNQezvLmfqykfHfM-9Hg452332-hEJMr8_Loy335tVtkd4-ZWPAFhC6R_</recordid><startdate>201109</startdate><enddate>201109</enddate><creator>Nikolajevic-Starcevic, Jovana</creator><creator>Petrovic, Mojca Globocnik</creator><creator>Petrovic, Daniel</creator><general>Blackwell Publishing Asia</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201109</creationdate><title>A1/A2 polymorphism of the glycoprotein IIIa gene and diabetic retinopathy in Caucasians with type 2 diabetes</title><author>Nikolajevic-Starcevic, Jovana ; Petrovic, Mojca Globocnik ; Petrovic, Daniel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4180-b9e3edb4b52b6d40c79a7e420683a64c8ec11d94a21aee1a7f6d13cd2cbe5f123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Alleles</topic><topic>Biochemical analysis</topic><topic>Blood</topic><topic>Blood Glucose - metabolism</topic><topic>Case-Control Studies</topic><topic>Cholesterol</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Confidence intervals</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetic retinopathy</topic><topic>Diabetic Retinopathy - blood</topic><topic>Diabetic Retinopathy - genetics</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Eye</topic><topic>Fasting</topic><topic>Female</topic><topic>Gene polymorphism</topic><topic>genetic risk factor</topic><topic>Genotype</topic><topic>Glucose</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>glycoprotein IIIa PlA1/A2 polymorphism</topic><topic>Glycoproteins</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Insulin</topic><topic>Integrin beta3 - genetics</topic><topic>Lipoproteins</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial infarction</topic><topic>Ophthalmology</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Restriction fragment length polymorphism</topic><topic>Retinopathy</topic><topic>Risk Factors</topic><topic>Stroke</topic><topic>Thrombosis</topic><topic>Triglycerides</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nikolajevic-Starcevic, Jovana</creatorcontrib><creatorcontrib>Petrovic, Mojca Globocnik</creatorcontrib><creatorcontrib>Petrovic, Daniel</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical & experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nikolajevic-Starcevic, Jovana</au><au>Petrovic, Mojca Globocnik</au><au>Petrovic, Daniel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A1/A2 polymorphism of the glycoprotein IIIa gene and diabetic retinopathy in Caucasians with type 2 diabetes</atitle><jtitle>Clinical & experimental ophthalmology</jtitle><addtitle>Clin Exp Ophthalmol</addtitle><date>2011-09</date><risdate>2011</risdate><volume>39</volume><issue>7</issue><spage>665</spage><epage>672</epage><pages>665-672</pages><issn>1442-6404</issn><eissn>1442-9071</eissn><abstract>Background: A PlA1/A2 polymorphism of glycoprotein IIIa is known to be involved in the pathogenesis of arterial thrombosis, myocardial infarction, stroke and type 2 diabetes, but there is no evidence of association with diabetic retinopathy. The aim of this study was to examine the role of the PlA1/A2 polymorphism of the glycoprotein IIIa gene in the development of diabetic retinopathy in Caucasians with type 2 diabetes.
Design: Cross‐sectional case–control study.
Participants: Totally 222 patients with diabetic retinopathy and 120 diabetic subjects without clinical signs of diabetic retinopathy from the Eye Clinic, University Medical Centre Ljubljana were enrolled in the study.
Methods: Fundus examination and blood biochemical analysis were performed. The polymerase chain reaction and restriction fragment length polymorphism were used.
Main Outcome Measures: The total cholesterol, triglyceride, high‐density lipoprotein levels, fasting blood glucose and HbA1c were measured, and the genotypes of the PlA1/A2 polymorphism were determined.
Results: Patients with diabetic retinopathy had earlier onset, longer duration of type 2 diabetes and a higher incidence of insulin therapy compared to the diabetic patients without diabetic retinopathy. A significantly lower frequency of the A2A2 genotype of glycoprotein IIIa was found in diabetic patients with retinopathy compared to those without retinopathy (odds ratio = 0.49, 95% confidence interval = 0.28–0.89; P = 0.018).
Conclusions: The A2A2 genotype of the glycoprotein IIIa polymorphism was associated with lower risk for diabetic retinopathy in Caucasians with type 2 diabetes. Further studies are needed to elucidate its protective role in the development of diabetic retinopathy in Caucasians.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>22452684</pmid><doi>10.1111/j.1442-9071.2011.02520.x</doi><tpages>8</tpages></addata></record> |
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| ispartof | Clinical & experimental ophthalmology, 2011-09, Vol.39 (7), p.665-672 |
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| subjects | Aged Alleles Biochemical analysis Blood Blood Glucose - metabolism Case-Control Studies Cholesterol Cholesterol, HDL - blood Cholesterol, LDL - blood Confidence intervals Cross-Sectional Studies Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - genetics Diabetic retinopathy Diabetic Retinopathy - blood Diabetic Retinopathy - genetics European Continental Ancestry Group - genetics Eye Fasting Female Gene polymorphism genetic risk factor Genotype Glucose Glycated Hemoglobin A - metabolism glycoprotein IIIa PlA1/A2 polymorphism Glycoproteins Heart attacks Humans Insulin Integrin beta3 - genetics Lipoproteins Male Middle Aged Myocardial infarction Ophthalmology Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide - genetics Restriction fragment length polymorphism Retinopathy Risk Factors Stroke Thrombosis Triglycerides Triglycerides - blood |
| title | A1/A2 polymorphism of the glycoprotein IIIa gene and diabetic retinopathy in Caucasians with type 2 diabetes |
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