Three single nucleotide variants of the SIRT1 gene are associated with overweight in a Chinese population: a case control study

We aimed to explore whether common allelic variations in the SIRT1 gene were associated with excess body weight in a Chinese cohort. Using standard molecular techniques 820 non-diabetic individuals, some of who were classified as overweight (> 23 Kg/m2), were genotyped for four haplotype-tagged s...

Full description

Saved in:
Bibliographic Details
Published in:Endocrine Journal 2012, Vol.59(3), pp.229-237
Main Authors: Zheng, Juan, Chen, Lu-Lu, Xiao, Fangxi, Hu, Xiang, Deng, Xiulin, Li, Huiqing
Format: Article
Language:English
Subjects:
Adult
Aged
Alleles
Asian Continental Ancestry Group - genetics
Body Mass Index
Case-Control Studies
China
Chinese population
Female
Gene Frequency
Genetic association
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Haplotypes
Humans
Male
Middle Aged
Overweight
Overweight - genetics
Polymorphism, Single Nucleotide
Single nucleotide polymorphisms
SIRT1 gene
Sirtuin 1 - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We aimed to explore whether common allelic variations in the SIRT1 gene were associated with excess body weight in a Chinese cohort. Using standard molecular techniques 820 non-diabetic individuals, some of who were classified as overweight (> 23 Kg/m2), were genotyped for four haplotype-tagged single nucleotide polymorphisms. The rs10509291AA and rs10823116GG genotypes were associated with high body mass index (BMI) > 23 Kg/m2, and the rs7894483TT genotype was associated with lower BMI (< 23 Kg/m2). The rs10509291AT genotype was associated with a modestly higher risk of being overweight, consistent with the presence of an rs10509291A being a dominant or semi-dominant allele. The ATAA (rs7894483/rs10823116) and ATAG haplotypes were associated with a higher risk of being overweight (OR: 17.11 and 5.12) compared with the AAAG haplotype (P 23 Kg/m2) and with overweight in this non-diabetic Chinese population.
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.EJ11-0234