Effect of stress testing on left ventricular mechanical synchrony by phase analysis of gated positron emission tomography in patients with normal myocardial perfusion

Purpose There are limited data on whether differences exist in left ventricular (LV) mechanical dyssynchrony indices derived from stress versus rest gated positron emission tomography (PET) in patients with normal myocardial perfusion imaging (MPI). Methods Stress/rest 82 Rb gated PET was performed...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2012-04, Vol.39 (4), p.665-672
Main Authors: AlJaroudi, Wael, Alraies, M. Chadi, DiFilippo, Frank, Brunken, Richard C., Cerqueira, Manuel D., Jaber, Wael A.
Format: Article
Language:English
Subjects:
Age
Biomechanical Phenomena
Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography - methods
Cardiology
Cardiomyopathy
Computed tomography
Data processing
Female
Heart
Hemodynamics
Humans
Hybrids
Imaging
Male
Mechanical Phenomena
Medical imaging
Medicine
Medicine & Public Health
Middle Aged
Myocardial Perfusion Imaging
Nuclear Medicine
Oncology
Original Article
Orthopedics
Perfusion
Positron emission tomography
Radiology
Standard deviation
Stress
Stress, Physiological
Tomography
Ventricle
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - physiopathology
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Summary:Purpose There are limited data on whether differences exist in left ventricular (LV) mechanical dyssynchrony indices derived from stress versus rest gated positron emission tomography (PET) in patients with normal myocardial perfusion imaging (MPI). Methods Stress/rest 82 Rb gated PET was performed in consecutive patients with normal MPI between 2006 and 2010. Patients were divided into two groups: group 1 [LV ejection fraction (EF) ≥ 55% and QRS < 120 ms] and group 2 (LVEF ≤35%). Images were acquired on a dedicated PET scanner prior to and on a hybrid PET/CT system after November 2008. LV dyssynchrony indices [phase standard deviation (SD)° and SD (ms)] were derived from stress and rest gated images. Results There were 91 patients in group 1 (age 61 ± 13, LVEF 66 ± 8%, normal QRS) and 126 in group 2 (age 66 ± 12, LVEF 25 ± 7%). The stress derived LVEF were significantly higher than rest for either group ( p  
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-011-2025-4