Changes in blood oxidative and antioxidant parameters in a group of Chinese patients with age-related macular degeneration

• Published in: The Journal of nutrition, health & aging health & aging, 2012-03, Vol.16 (3), p.201-204
• Main Authors: Shen, Xueli, Jia, L. H, Zhao, P, Fan, R, Pan, X. Y, Yang, H. M, Liu, L
• Format: Article
• Language: English
• Subjects: Age; Aging; antioxidant activity; Antioxidants; Antioxidants - administration & dosage; Antioxidants - metabolism; ascorbic acid; Ascorbic Acid - metabolism; Asian People; Biological and medical sciences; Biomarkers - blood; blood; Blood Chemical Analysis; blood lipids; Body mass index; Case-Control Studies; Chinese people; Disease; enzyme activity; Feeding Behavior; Feeding. Feeding behavior; Female; Food; fruit consumption; Fundamental and applied biological sciences. Psychology; Geriatrics/Gerontology; Hospitals; Humans; JNHA: Nutrition; Legumes; Lipid Peroxidation; Macular degeneration; Macular Degeneration - blood; Macular Degeneration - enzymology; Male; malondialdehyde; Malondialdehyde - blood; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Neurosciences; Nutrition; Nutrition research; Ophthalmology; Oxidation-Reduction; Pathogenesis; patients; Primary Care Medicine; Quality of Life Research; Questionnaires; redox reactions; Retinopathies; Risk factors; superoxide dismutase; Superoxide Dismutase - metabolism; Vertebrates: anatomy and physiology, studies on body, several organs or systems; vision disorders; Vitamin C; vitamin E; Vitamin E - metabolism
• ISSN: 1279-7707; 1760-4788
• DOI: 10.1007/s12603-011-0350-8

OBJECTIVE: To measure the oxidative and antioxidant biochemical parameters in the serum of Chinese patients with age-related macular degeneration (AMD) and in a similar age control group from the same area. DESIGN: A case-control study. PARTICIPANTS: 56 AMD patients (21 early dry, 13 geographic atrophy and 22 wet form) and 34 normal subjects, similar for age and sex were studied. MEASUREMENTS: Both groups completed a questionnaire about demographic characters and dieatry habit, and the levels of serum lipid peroxidation (malondialdehyde, MDA) and antioxidants parameters (vitamin C and E, the activities of superoxide dismutase-SOD, total antioxidant capacity — TAC) were determined. RESULTS: There was a significantly higher frequency of daily intake of fruit and legumes in controls than in AMD patients. There was a significantly increased serum MDA levels and SOD activities, and significantly decreased serum vitamin C and total antioxidant capacity in AMD patients as compared to controls. The intensity of lipid peroxidation was higher with the progression of AMD. There was not difference in serum vitamin E levels between AMD patients and controls. CONCLUSION: Oxido-reduction disturbance may be involved in the pathogenesis of AMD. There is a significantly decreased antioxidant capacity in AMD patients.