Success rates of a mixture of ciprofloxacin, metronidazole, and minocycline antibiotics used in the non-instrumentation endodontic treatment of mandibular primary molars with carious pulpal involvement

• Published in: International journal of paediatric dentistry 2012-05, Vol.22 (3), p.217-227
• Main Authors: TRAIRATVORAKUL, CHUTIMA, DETSOMBOONRAT, PALINEE
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - therapeutic use; Anti-Infective Agents - administration & dosage; Anti-Infective Agents - therapeutic use; Antibiotics; Bisphenol A-Glycidyl Methacrylate - chemistry; Child; Child, Preschool; Ciprofloxacin - administration & dosage; Ciprofloxacin - therapeutic use; Composite Resins - chemistry; Crowns; Dental Alloys - chemistry; Dental Caries - therapy; Dental Materials - chemistry; Dental Pulp Exposure - therapy; Dental Pulp Necrosis - therapy; Dentistry; Drug Combinations; Follow-Up Studies; Glass Ionomer Cements - chemistry; Humans; Mandible; Metronidazole - administration & dosage; Metronidazole - therapeutic use; Minocycline - administration & dosage; Minocycline - therapeutic use; Molar - pathology; Organophosphates - chemistry; Pulpotomy - methods; Radiography, Bitewing; Resins, Synthetic - chemistry; Root Canal Irrigants - therapeutic use; Stainless Steel - chemistry; Success; Tooth, Deciduous - pathology; Treatment Outcome
• ISSN: 0960-7439; 1365-263X
• DOI: 10.1111/j.1365-263X.2011.01181.x

International Journal of Paediatric Dentistry 2012; 22: 217–227 Objective.  To evaluate the clinical and radiographic success rates of three mixed antibiotics in the non‐instrumentation endodontic treatment of primary mandibular molars at 24–27 months postoperatively. Methods.  Eighty cariously involved lower primary molars from 58 children (ages 3–8 years) received a 3Mix medicament by non‐instrumentation endodontic treatment and were then sealed with glass‐ionomer cement and composite resin before permanent restoration with stainless steel crowns. The patients received a clinical and radiographic assessment every 6 months over a 2‐year follow‐up period with an intra‐examiner reliability of 0.83–1.00 (κ value). Results.  In 60 cases at 24‐ to 27‐month follow‐up, the success rates as determined by clinical and radiographic evaluation were 75% and 36.7%, respectively; however, the overall success rate of 3Mix non‐instrumentation endodontic treatment was 36.7% with 15.8% of cases demonstrating a pulpal response of internal resorption. Conclusions.  Non‐instrumentation endodontic treatment using 3Mix‐MP showed good clinical success but had a low success rate based on radiographic evaluation at 2‐year follow‐up. Hence, 3Mix antibiotic treatment cannot replace a conventional root canal treatment agent as a long‐term therapy.