Effect of supplementation with an electrolyte containing a Bacillus-based direct-fed microbial on immune development in dairy calves

Immune characteristics in 65 calves were evaluated in response to a Bacillus-based direct-fed microbial (DFM) provided in electrolyte scour treatment. Blood samples were analyzed for cell surface markers and α1-acid glycoprotein (AGP) concentration. AGP increased in scouring calves given electrolyte...

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Bibliographic Details
Published in:Research in veterinary science 2012-06, Vol.92 (3), p.427-434
Main Authors: Novak, K.N., Davis, E., Wehnes, C.A., Shields, D.R., Coalson, J.A., Smith, A.H., Rehberger, T.G.
Format: Article
Language:English
Subjects:
Animal Feed - analysis
Animal sciences
Animals
Bacillus
Bacillus subtilis - physiology
Bacteria
Calf
Cattle - immunology
Cattle Diseases - drug therapy
Dairying
Diarrhea - drug therapy
Diarrhea - veterinary
Diet - veterinary
Dietary Supplements
Electrolytes - therapeutic use
Glycoproteins - metabolism
Homeostasis
Immune system
Immunity
Immunology
Inflammation
Lymphocyte Subsets - drug effects
Lymphocyte Subsets - physiology
Lymphocytes
Male
Probiotic
Probiotics
Probiotics - therapeutic use
T cell receptors
Veterinary medicine
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Summary:Immune characteristics in 65 calves were evaluated in response to a Bacillus-based direct-fed microbial (DFM) provided in electrolyte scour treatment. Blood samples were analyzed for cell surface markers and α1-acid glycoprotein (AGP) concentration. AGP increased in scouring calves given electrolyte containing Bacillus at day 7 post-placement compared to scouring calves administered electrolyte alone and non-scouring calves, enhancing the inflammatory response for pathogen clearance. The Bacillus promotes T cell subsets including greater proportions of activated, mature cells (CD8−CD25+, CD8−CD45RO+, CD8−TCR1+) in calves given electrolyte containing Bacillus than scouring calves administered electrolyte alone and non-scouring calves. Also, the Bacillus may be alleviating inflammation at day 3 post-placement as the proportion of monocytes and granulocytes lacking L-selectin (CD172a+CD62L−) was greater in scouring calves given electrolyte compared to the other groups. Electrolyte containing Bacillus administered at the onset of scours influences components of innate and adaptive immune development during and following the scouring event.
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2011.04.008