Database screening and in vivo efficacy of antimicrobial peptides against methicillin-resistant Staphylococcus aureus USA300

Natural antimicrobial peptides (AMPs) are promising candidates for developing a generation of new antimicrobials to meet the challenge of antibiotic-resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA). To facilitate the search for new candidates, we have utilised the Antim...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2012-05, Vol.39 (5), p.402-406
Main Authors: Menousek, Joseph, Mishra, Biswajit, Hanke, Mark L, Heim, Cortney E, Kielian, Tammy, Wang, Guangshun
Format: Article
Language:English
Subjects:
amphibians
animal models
Animals
antibacterial properties
antibiotic resistance
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimicrobial Cationic Peptides - genetics
Antimicrobial Cationic Peptides - pharmacology
Antimicrobial Cationic Peptides - therapeutic use
Antimicrobial peptides
Arachnida
Bacillus subtilis
Bacillus subtilis - drug effects
bacteria
Bacterial diseases
Bacterial Proteins - genetics
Bacterial Proteins - pharmacology
Bacterial Proteins - therapeutic use
biofilm
Biofilms
Biological and medical sciences
Disease Models, Animal
Drug Evaluation, Preclinical
Escherichia coli
Escherichia coli - drug effects
fish
Fungal Proteins - genetics
Fungal Proteins - pharmacology
Fungal Proteins - therapeutic use
fungi
Human bacterial diseases
Infectious Disease
Infectious diseases
insects
Male
mammals
Medical sciences
methicillin
Methicillin-resistant Staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus - drug effects
Mice
Mice, Inbred C57BL
Microbial Sensitivity Tests
pathogens
Pharmacology. Drug treatments
Plant Proteins - genetics
Plant Proteins - pharmacology
Plant Proteins - therapeutic use
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
screening
Staphylococcal Infections - drug therapy
Staphylococcal Infections - microbiology
Staphylococcal infections, streptococcal infections, pneumococcal infections
Staphylococcus aureus
Tunicata
Urochordata
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Description
Summary:Natural antimicrobial peptides (AMPs) are promising candidates for developing a generation of new antimicrobials to meet the challenge of antibiotic-resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA). To facilitate the search for new candidates, we have utilised the Antimicrobial Peptide Database (APD), which contains natural AMPs from bacteria, fungi, plants and animals. This study demonstrates the identification of novel templates against MRSA by screening 30 peptides selected from the APD. These peptides are short (
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2012.02.003