Loading…
Sensitivities of ciprofloxacin-resistant Mycobacterium tuberculosis clinical isolates to fluoroquinolones: role of mutant DNA gyrase subunits in drug resistance
Minimum inhibitory concentrations of sitafloxacin, gatifloxacin, moxifloxacin, sparfloxacin, levofloxacin and ciprofloxacin against 59 ciprofloxacin-resistant clinical isolates of Mycobacterium tuberculosis from Japan were determined. The isolates were most susceptible to sitafloxacin and gatifloxac...
Saved in:
| Published in: | International journal of antimicrobial agents 2012-05, Vol.39 (5), p.435-439 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c551t-b025f6b685fc546a5fec79e9da0c98d8e1cac52830db4e86c5af90427505218d3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c551t-b025f6b685fc546a5fec79e9da0c98d8e1cac52830db4e86c5af90427505218d3 |
| container_end_page | 439 |
| container_issue | 5 |
| container_start_page | 435 |
| container_title | International journal of antimicrobial agents |
| container_volume | 39 |
| creator | Suzuki, Yasuhiko Nakajima, Chie Tamaru, Aki Kim, Hyun Matsuba, Takashi Saito, Hajime |
| description | Minimum inhibitory concentrations of sitafloxacin, gatifloxacin, moxifloxacin, sparfloxacin, levofloxacin and ciprofloxacin against 59 ciprofloxacin-resistant clinical isolates of Mycobacterium tuberculosis from Japan were determined. The isolates were most susceptible to sitafloxacin and gatifloxacin. To understand better the basis for drug resistance, nucleotide sequences encoding the gyrA and gyrB quinolone resistance-determining region were determined. Predicted amino acid sequences revealed distinct mutational patterns likely to be responsible for fluoroquinolone resistance. Double gyrA mutations as well as mutations in both gyrA and gyrB correlated with increased resistance to all fluoroquinolones. |
| doi_str_mv | 10.1016/j.ijantimicag.2012.01.007 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_963829922</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0924857912000489</els_id><sourcerecordid>963829922</sourcerecordid><originalsourceid>FETCH-LOGICAL-c551t-b025f6b685fc546a5fec79e9da0c98d8e1cac52830db4e86c5af90427505218d3</originalsourceid><addsrcrecordid>eNqNks2O0zAUhSMEYjoDrwBmgWaVYjtxYrNAGpVfaYBFmbXlONeVSxJ3_DOib8Oj4kxbQKxYWF74u_ccneOieEHwkmDSvNou7VZN0Y5Wq82SYkKXmCwxbh8UC8JbWraCVA-LBRa0LjlrxVlxHsIWY8Kqmj0uziitKakoXxQ_1zAFG-1dPhCQM0jbnXdmcD-UtlPpIdgQsxj6vNeuUzqCt2lEMXXgdRpcfkZ6sFO2MiAb3KBi3hMdMkNy3t0mO7nBTRBeI-8GmBXGdL_w7ZcrtNl7FQCF1KXJxoDshHqfNugkq-FJ8cioIcDT431R3Lx_9231sbz--uHT6uq61IyRWHaYMtN0DWdGs7pRzIBuBYheYS14z4FopRnlFe67GnijmTIC17RlmFHC--qiuDzs3c2mIUQ52qBhGNQELgUpmopTISjNpDiQ2rsQPBi583ZUfi8JlnM_civ_6kfO_UhMZO4nzz47qqRuhP735KmQDLw8AirkRI3PGdjwh2Nt07b3Jp4fOKOcVBufmZt1VmK5ZE5ZQzKxOhCQU7uz4GXQFnKivfWgo-yd_S_Db_7Zcir7O-whbF3yU65FEhnyjFzPX27-cYRijGsuql-1IdfG</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>963829922</pqid></control><display><type>article</type><title>Sensitivities of ciprofloxacin-resistant Mycobacterium tuberculosis clinical isolates to fluoroquinolones: role of mutant DNA gyrase subunits in drug resistance</title><source>ScienceDirect Journals</source><creator>Suzuki, Yasuhiko ; Nakajima, Chie ; Tamaru, Aki ; Kim, Hyun ; Matsuba, Takashi ; Saito, Hajime</creator><creatorcontrib>Suzuki, Yasuhiko ; Nakajima, Chie ; Tamaru, Aki ; Kim, Hyun ; Matsuba, Takashi ; Saito, Hajime</creatorcontrib><description>Minimum inhibitory concentrations of sitafloxacin, gatifloxacin, moxifloxacin, sparfloxacin, levofloxacin and ciprofloxacin against 59 ciprofloxacin-resistant clinical isolates of Mycobacterium tuberculosis from Japan were determined. The isolates were most susceptible to sitafloxacin and gatifloxacin. To understand better the basis for drug resistance, nucleotide sequences encoding the gyrA and gyrB quinolone resistance-determining region were determined. Predicted amino acid sequences revealed distinct mutational patterns likely to be responsible for fluoroquinolone resistance. Double gyrA mutations as well as mutations in both gyrA and gyrB correlated with increased resistance to all fluoroquinolones.</description><identifier>ISSN: 0924-8579</identifier><identifier>EISSN: 1872-7913</identifier><identifier>DOI: 10.1016/j.ijantimicag.2012.01.007</identifier><identifier>PMID: 22421328</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>amino acid sequences ; Amino Acid Substitution ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antitubercular Agents - pharmacology ; Biological and medical sciences ; ciprofloxacin ; Ciprofloxacin - pharmacology ; DNA Gyrase - genetics ; DNA topoisomerase (ATP-hydrolysing) ; DNA, Bacterial - chemistry ; DNA, Bacterial - genetics ; drug resistance ; Drug Resistance, Bacterial ; Fluoroquinolone resistance ; Fluoroquinolones - pharmacology ; gyrA ; gyrB ; Humans ; Infectious Disease ; Japan ; Medical sciences ; Microbial Sensitivity Tests ; minimum inhibitory concentration ; mutants ; mutation ; Mutation, Missense ; Mutations ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - drug effects ; Mycobacterium tuberculosis - isolation & purification ; nucleotide sequences ; Pharmacology. Drug treatments ; Protein Subunits - genetics ; Sequence Analysis, DNA ; sitafloxacin ; sparfloxacin ; Tuberculosis - microbiology</subject><ispartof>International journal of antimicrobial agents, 2012-05, Vol.39 (5), p.435-439</ispartof><rights>Elsevier B.V. and the International Society of Chemotherapy</rights><rights>2012 Elsevier B.V. and the International Society of Chemotherapy</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-b025f6b685fc546a5fec79e9da0c98d8e1cac52830db4e86c5af90427505218d3</citedby><cites>FETCH-LOGICAL-c551t-b025f6b685fc546a5fec79e9da0c98d8e1cac52830db4e86c5af90427505218d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25767722$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22421328$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suzuki, Yasuhiko</creatorcontrib><creatorcontrib>Nakajima, Chie</creatorcontrib><creatorcontrib>Tamaru, Aki</creatorcontrib><creatorcontrib>Kim, Hyun</creatorcontrib><creatorcontrib>Matsuba, Takashi</creatorcontrib><creatorcontrib>Saito, Hajime</creatorcontrib><title>Sensitivities of ciprofloxacin-resistant Mycobacterium tuberculosis clinical isolates to fluoroquinolones: role of mutant DNA gyrase subunits in drug resistance</title><title>International journal of antimicrobial agents</title><addtitle>Int J Antimicrob Agents</addtitle><description>Minimum inhibitory concentrations of sitafloxacin, gatifloxacin, moxifloxacin, sparfloxacin, levofloxacin and ciprofloxacin against 59 ciprofloxacin-resistant clinical isolates of Mycobacterium tuberculosis from Japan were determined. The isolates were most susceptible to sitafloxacin and gatifloxacin. To understand better the basis for drug resistance, nucleotide sequences encoding the gyrA and gyrB quinolone resistance-determining region were determined. Predicted amino acid sequences revealed distinct mutational patterns likely to be responsible for fluoroquinolone resistance. Double gyrA mutations as well as mutations in both gyrA and gyrB correlated with increased resistance to all fluoroquinolones.</description><subject>amino acid sequences</subject><subject>Amino Acid Substitution</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antitubercular Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>ciprofloxacin</subject><subject>Ciprofloxacin - pharmacology</subject><subject>DNA Gyrase - genetics</subject><subject>DNA topoisomerase (ATP-hydrolysing)</subject><subject>DNA, Bacterial - chemistry</subject><subject>DNA, Bacterial - genetics</subject><subject>drug resistance</subject><subject>Drug Resistance, Bacterial</subject><subject>Fluoroquinolone resistance</subject><subject>Fluoroquinolones - pharmacology</subject><subject>gyrA</subject><subject>gyrB</subject><subject>Humans</subject><subject>Infectious Disease</subject><subject>Japan</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>minimum inhibitory concentration</subject><subject>mutants</subject><subject>mutation</subject><subject>Mutation, Missense</subject><subject>Mutations</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - drug effects</subject><subject>Mycobacterium tuberculosis - isolation & purification</subject><subject>nucleotide sequences</subject><subject>Pharmacology. Drug treatments</subject><subject>Protein Subunits - genetics</subject><subject>Sequence Analysis, DNA</subject><subject>sitafloxacin</subject><subject>sparfloxacin</subject><subject>Tuberculosis - microbiology</subject><issn>0924-8579</issn><issn>1872-7913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqNks2O0zAUhSMEYjoDrwBmgWaVYjtxYrNAGpVfaYBFmbXlONeVSxJ3_DOib8Oj4kxbQKxYWF74u_ccneOieEHwkmDSvNou7VZN0Y5Wq82SYkKXmCwxbh8UC8JbWraCVA-LBRa0LjlrxVlxHsIWY8Kqmj0uziitKakoXxQ_1zAFG-1dPhCQM0jbnXdmcD-UtlPpIdgQsxj6vNeuUzqCt2lEMXXgdRpcfkZ6sFO2MiAb3KBi3hMdMkNy3t0mO7nBTRBeI-8GmBXGdL_w7ZcrtNl7FQCF1KXJxoDshHqfNugkq-FJ8cioIcDT431R3Lx_9231sbz--uHT6uq61IyRWHaYMtN0DWdGs7pRzIBuBYheYS14z4FopRnlFe67GnijmTIC17RlmFHC--qiuDzs3c2mIUQ52qBhGNQELgUpmopTISjNpDiQ2rsQPBi583ZUfi8JlnM_civ_6kfO_UhMZO4nzz47qqRuhP735KmQDLw8AirkRI3PGdjwh2Nt07b3Jp4fOKOcVBufmZt1VmK5ZE5ZQzKxOhCQU7uz4GXQFnKivfWgo-yd_S_Db_7Zcir7O-whbF3yU65FEhnyjFzPX27-cYRijGsuql-1IdfG</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Suzuki, Yasuhiko</creator><creator>Nakajima, Chie</creator><creator>Tamaru, Aki</creator><creator>Kim, Hyun</creator><creator>Matsuba, Takashi</creator><creator>Saito, Hajime</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120501</creationdate><title>Sensitivities of ciprofloxacin-resistant Mycobacterium tuberculosis clinical isolates to fluoroquinolones: role of mutant DNA gyrase subunits in drug resistance</title><author>Suzuki, Yasuhiko ; Nakajima, Chie ; Tamaru, Aki ; Kim, Hyun ; Matsuba, Takashi ; Saito, Hajime</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c551t-b025f6b685fc546a5fec79e9da0c98d8e1cac52830db4e86c5af90427505218d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>amino acid sequences</topic><topic>Amino Acid Substitution</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antitubercular Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>ciprofloxacin</topic><topic>Ciprofloxacin - pharmacology</topic><topic>DNA Gyrase - genetics</topic><topic>DNA topoisomerase (ATP-hydrolysing)</topic><topic>DNA, Bacterial - chemistry</topic><topic>DNA, Bacterial - genetics</topic><topic>drug resistance</topic><topic>Drug Resistance, Bacterial</topic><topic>Fluoroquinolone resistance</topic><topic>Fluoroquinolones - pharmacology</topic><topic>gyrA</topic><topic>gyrB</topic><topic>Humans</topic><topic>Infectious Disease</topic><topic>Japan</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>minimum inhibitory concentration</topic><topic>mutants</topic><topic>mutation</topic><topic>Mutation, Missense</topic><topic>Mutations</topic><topic>Mycobacterium tuberculosis</topic><topic>Mycobacterium tuberculosis - drug effects</topic><topic>Mycobacterium tuberculosis - isolation & purification</topic><topic>nucleotide sequences</topic><topic>Pharmacology. Drug treatments</topic><topic>Protein Subunits - genetics</topic><topic>Sequence Analysis, DNA</topic><topic>sitafloxacin</topic><topic>sparfloxacin</topic><topic>Tuberculosis - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suzuki, Yasuhiko</creatorcontrib><creatorcontrib>Nakajima, Chie</creatorcontrib><creatorcontrib>Tamaru, Aki</creatorcontrib><creatorcontrib>Kim, Hyun</creatorcontrib><creatorcontrib>Matsuba, Takashi</creatorcontrib><creatorcontrib>Saito, Hajime</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of antimicrobial agents</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suzuki, Yasuhiko</au><au>Nakajima, Chie</au><au>Tamaru, Aki</au><au>Kim, Hyun</au><au>Matsuba, Takashi</au><au>Saito, Hajime</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sensitivities of ciprofloxacin-resistant Mycobacterium tuberculosis clinical isolates to fluoroquinolones: role of mutant DNA gyrase subunits in drug resistance</atitle><jtitle>International journal of antimicrobial agents</jtitle><addtitle>Int J Antimicrob Agents</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>39</volume><issue>5</issue><spage>435</spage><epage>439</epage><pages>435-439</pages><issn>0924-8579</issn><eissn>1872-7913</eissn><abstract>Minimum inhibitory concentrations of sitafloxacin, gatifloxacin, moxifloxacin, sparfloxacin, levofloxacin and ciprofloxacin against 59 ciprofloxacin-resistant clinical isolates of Mycobacterium tuberculosis from Japan were determined. The isolates were most susceptible to sitafloxacin and gatifloxacin. To understand better the basis for drug resistance, nucleotide sequences encoding the gyrA and gyrB quinolone resistance-determining region were determined. Predicted amino acid sequences revealed distinct mutational patterns likely to be responsible for fluoroquinolone resistance. Double gyrA mutations as well as mutations in both gyrA and gyrB correlated with increased resistance to all fluoroquinolones.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>22421328</pmid><doi>10.1016/j.ijantimicag.2012.01.007</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0924-8579 |
| ispartof | International journal of antimicrobial agents, 2012-05, Vol.39 (5), p.435-439 |
| issn | 0924-8579 1872-7913 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_963829922 |
| source | ScienceDirect Journals |
| subjects | amino acid sequences Amino Acid Substitution Antibiotics. Antiinfectious agents. Antiparasitic agents Antitubercular Agents - pharmacology Biological and medical sciences ciprofloxacin Ciprofloxacin - pharmacology DNA Gyrase - genetics DNA topoisomerase (ATP-hydrolysing) DNA, Bacterial - chemistry DNA, Bacterial - genetics drug resistance Drug Resistance, Bacterial Fluoroquinolone resistance Fluoroquinolones - pharmacology gyrA gyrB Humans Infectious Disease Japan Medical sciences Microbial Sensitivity Tests minimum inhibitory concentration mutants mutation Mutation, Missense Mutations Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - isolation & purification nucleotide sequences Pharmacology. Drug treatments Protein Subunits - genetics Sequence Analysis, DNA sitafloxacin sparfloxacin Tuberculosis - microbiology |
| title | Sensitivities of ciprofloxacin-resistant Mycobacterium tuberculosis clinical isolates to fluoroquinolones: role of mutant DNA gyrase subunits in drug resistance |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-30T21%3A26%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sensitivities%20of%20ciprofloxacin-resistant%20Mycobacterium%20tuberculosis%20clinical%20isolates%20to%20fluoroquinolones:%20role%20of%20mutant%20DNA%20gyrase%20subunits%20in%20drug%20resistance&rft.jtitle=International%20journal%20of%20antimicrobial%20agents&rft.au=Suzuki,%20Yasuhiko&rft.date=2012-05-01&rft.volume=39&rft.issue=5&rft.spage=435&rft.epage=439&rft.pages=435-439&rft.issn=0924-8579&rft.eissn=1872-7913&rft_id=info:doi/10.1016/j.ijantimicag.2012.01.007&rft_dat=%3Cproquest_cross%3E963829922%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c551t-b025f6b685fc546a5fec79e9da0c98d8e1cac52830db4e86c5af90427505218d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=963829922&rft_id=info:pmid/22421328&rfr_iscdi=true |